ABERRANT

作品数：201被引量：605H指数：12
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相关领域：医药卫生更多>>
相关作者：杨音杨楠孙鸾张欣孙玉洁更多>>
相关机构：第二军医大学第三军医大学西南医院南京医科大学湖州市第三人民医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
《Bone Research》2024年第2期289-301,共13页Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi 
supported by NIH R01 AR078324 and R01 AR071379.
While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury r...
关键词：METABOLISM SKELETAL ABERRANT 
Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma被引量：2
《Bone Research》2022年第3期615-626,共12页Qizhi Qin Mario Gomez-Salazar Masnsen Cherief Chase A.Pagani Seungyong Lee Charles Hwang Robert J.Tower Sharon Onggo Yuxiao Sun Abhinav Piplani Zhao Li Sowmya Ramesh Thomas L.Clemens Benjamin Levi Aaron W.James 
JHU microscopy facility.A.W.J.was funded by NIH/NIAMS(R01 AR070773),NIH/NIDCR(R21 DE027922);USAMRAA through the Peer-Reviewed Medical Research Program(W81XWH-18–1–0121,W81XWH-18–1–0336);Broad Agency Announcement(W81XWH-18–10613);American Cancer Society(Research Scholar Grant,RSG-18–027–01-CSM);the Maryland Stem Cell Research Foundation.B.L.funded by the NIH(1R01 AR071379);funded by NIH(R01 AR079171);Do D(W81XWH-20–1–0795);supported by the NIH/NIAMS(R01 AR068934);NIH/NIDCR(R21 DE027922);the VA(Merit Award and Senior Research Career Scientist Award)。
The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of...
关键词：ABERRANT TRAUMA NERVES 
Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice被引量：2
《Bone Research》2022年第1期65-80,共16页Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie 
supported by grants from the National Key Research and Development Program of China (2018YFA0800802);the National Natural Science Foundation of China (81830075, 81772306, 81530071, and 81991513);the Chongqing Talent Plan (CQYC202001008 and CQYC202005088)
The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease...
关键词：HIF1Α DEGENERATION ABERRANT 
Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification被引量：4
《Bone Research》2019年第4期371-387,共17页Charles Hwang Simone Marini Amanda KHuber David MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle DVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina Shailesh Agarwal Jun Li Benjamin Levi 
B.L.:Supported by funding from NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH1R01AR071379;American College of Surgeons Clowes Award.D.M.S.:Supported by Plastic Surgery Foundation Resident Research Award;M.S.:Supported by Plastic Surgery Foundation National Endowment Award;C.H.:Supported by Howard Hughes Medical Institute Medical Research Fellowship;J.L.:Supported by Vascular Surgery T32 5-T32-HL-076123–14;A.W.J.:Supported by the NIH/NIAMS(R01 AR070773,K08 AR068316,S10OD016374);the Orthopedic Research and Education Foundation with funding provided by the Maryland Stem Cell Research Foundation,and the Musculoskeletal Transplant Foundation;P.B.Y.:Supported by funding from NIH/NIAMS R01 AR057374 and NHLBI R01 HL131910;Y.M.:Supported by funding from NIH/NIDCR R01 DE020843 and DE027662
Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic bone.HO occurs commonly following orthopedic surgeries,burns,and neurologic injuries.While surgical excision...
关键词：VEGFA INJURIES OSSIFICATION 
Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis被引量：16
《Bone Research》2018年第4期383-392,共10页Liwei Zheng Caixia Pi Jun Zhang Yi Fan Chen Cui Yang Zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao Xuedong Zhou 
supported by 2016JQ0054 and NSFC grants 81470711 to L.Z.;National Key Research and Development Program of China 2016YFC1102700 to X.Z.
There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transfo...
关键词：TMJ OA TMD Aberrant activation of latent transforming growth factor initiates the onset of temporomandibular joint osteoarthritis 
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