云南高校图书馆联盟文献共享服务平台- ADCS

ADCS: 作品数：58被引量：53H指数：3; 导出分析报告; 相关领域：电子电信医药卫生更多>>; 相关作者：范云六束锋张春义梁秋菊贾向东更多>>; 相关机构：中国农业科学院生物技术研究所南京理工大学南京邮电大学兰州大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中央级公益性科研院所基本科研业务费专项国家教育部博士点基金中国博士后科学基金更多>>

Unlocking the potential of bispecific ADCs for targeted cancer therapy被引量：1: 《Frontiers of Medicine》2024年第4期597-621,共25页Hongye Zeng Wenjing Ning Xue Liu Wenxin Luo Ningshao Xia; supported by the National Natural Science Foundation of China(Nos.32070940 and 81991491);China Postdoctoral Science Foundation(No.2021M700115);Postdoctoral Innovation Talents Support Program(No.BX20220189);CAMS Innovation Fund for Medical Sciences(No.2019RU022);Fundamental Research Funds for the Central Universities(No.20720220006).; Antibody–drug conjugates(ADCs)are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by linkers.These innovative compounds enable precise drug delivery to tumor cells,minimizing harm to ...; 关键词：antibody-drug conjugate bispecific antibody bispecific ADC CANCER

A 128×128 SPAD LiDAR sensor with column-parallel 25 ps resolution TA-ADCs被引量：1: 《Journal of Semiconductors》2024年第8期34-40,共7页Na Tian Zhe Wang Kai Ma Xu Yang Nan Qi Jian Liu Nanjian Wu Runjiang Dou Liyuan Liu; supported by National Science and Technology Major Project(Grant No.2021ZD0109801);in part by the Beijing Municipal Science and Technology Project(Grant No.Z221100007722028);in part by the National Natural Science Foundation of China(Grant No.62334008).; This paper presents a design of single photon avalanche diode(SPAD)light detection and ranging(LiDAR)sensor with 128×128 pixels and 128 column-parallel time-to-analog-merged-analog-to-digital converts(TA-ADCs).Unlike...; 关键词：3D imaging CMOS imagers direct time-of-flight(dTOF) time-to-analog converter(TAC)

瞄准未来:卵巢癌靶向治疗的新进展被引量：2: 《实用医学杂志》2024年第14期1901-1907,共7页黄山高吴月玲张颖; 广东省自然科学基金项目(编号:2017A030313559)。; 卵巢癌是对全球女性健康构成重大威胁的疾病之一,在中国,卵巢癌在妇科恶性肿瘤中的复发率和病死率最高。传统治疗对晚期或复发性卵巢癌患者效果有限。最近的研究表明,靶向治疗在卵巢癌的治疗中取得了重要进展。本文将聚焦于国内外卵巢...; 关键词：卵巢癌靶向治疗 PARP抑制剂 ADCS 研究进展

Antibody-Drug Conjugates (ADCs): Navigating Four Pillars of Safety, Development, Supply Chain and Manufacturing Excellence: 《Advances in Chemical Engineering and Science》2023年第4期351-362,共12页Kishore Kumar Hotha; Antibody-drug conjugates (ADCs) are pioneering biologics that merge antibodies’ specificity with small molecules’ potency. With a handful of FDA-approved ADCs in the market and many under development, ADCs are poise...; 关键词：Antibody Drug Conjugates ADC’s Payload LINKER Antibody HPAPI SAFETY Technology Transfer CDMO CMO

The ABC of ADCs (Antibody-Drug Conjugates): A Comprehensive Review of Technical, Regulatory, and Clinical Challenges: 《Advances in Chemical Engineering and Science》2023年第4期363-381,共19页Kishore Kumar Hotha; Over the past several decades, there has been a significant surge in the development of Antibody-Drug Conjugates (ADCs). Designing an ideal ADC presents a multifaceted challenge, requiring the precise orchestration of...; 关键词：Antibody-Drug Conjugates Cancer Therapy PAYLOAD LINKER Conjugation Chemistry ANTIBODY Analytical Development Manufacturing of ADCs

ADCs研发进展及其治疗尿路上皮癌的临床研究概述: 《现代医学》2023年第3期401-406,共6页曾艳游然韩彬; 四川省教育厅项目(18XB0219)。; 尿路上皮癌是晚期泌尿肿瘤中比较常见的类型,其发病率高、临床预后差,现有治疗方案未能满足临床需求。国内外在不断探索研发治疗尿路上皮癌的药物,其中抗体偶联药物(ADCs)也是一个重要的发展方向。本文作者就ADCs的发展及其在尿路上皮...; 关键词：尿路上皮癌药物治疗抗体偶联药物临床研究综述

The change of paradigm in the treatment of HER2-positive breast cancer with the development of newgeneration antibody-drug conjugates: 《Cancer Drug Resistance》2023年第1期45-58,共14页Santiago Escriva-de-Romani Cristina Saura; HER2-positive breast cancer is an aggressive disease.As a result of the development of specific HER2-targeted therapies,such as trastuzumab,more than 20 years ago,the prognosis of these patients has improved.Metastati...; 关键词：Breast cancer HER2-positive ADCS New drugs Mechanisms of resistance

基于STM32的管道变形检测数据采集系统的研究与实现被引量：1: 《中国特种设备安全》2022年第8期7-11,28,共6页熊治坤陈金忠马义来李春雨; 国家重点研发计划项目“典型城市民生设施质量检测与评价技术研究”(2018YFF0215000)。; 为了实现油气管道内检测几何变形数据的实时采集,本文重点研究了STM32的ADC(模拟-数字转换)功能,设计并实现了基于STM32的多通道数据采集系统。本文研制的油气管道内检测设备具有设备短小精悍、操作便捷、功耗低、单次检测里程长、质量...; 关键词：ADCS TM32 油气管道几何变形

Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera: 《Journal of Pharmaceutical Analysis》2022年第4期645-652,共8页Min Pei Tingting Liu Lu Ouyang Jianhua Sun Xiaojie Deng Xiaomin Sun Wei Wu Peng Huang Yi-Li Chen Xiaorong Tan Xiaoyue Liu Peng Zhu Yongzhen Liu Deheng Wang Junliang Wu Qi Wang Guifeng Wang Likun Gong Qiuping Qin Chunhe Wang; supported by the China National Major Scientific and Technological Special Project for“Significant New Drugs Innovation and Development”(Grant No.:2019ZX09732002-006);the National New Drug Creation Program of China(Grant No.:2018ZX09201017-004);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.:XDA12020223,XDA12020330,XDA12020360,and XDA12050305);the National Natural Science Foundation of China(Grant Nos.:81872785 and 81673347);the Science and Technology Planning Projects of Department of Science and Technology Province(Grant No.:20190202);Shanghai Municipal Commission of Science and Technology of China(Grant Nos.:17431904400,19YF1457400,and 21S11904500);Institutes for Drug Discovery and Development,the Chinese Academy of Sciences(Grant Nos.:CASIMM0120202007 and CASIMM0120202008);Major Scientific and Technological Special Project of Zhongshan City(Grant Nos.:191022172638719 and 210205143867019).; Antibody-drug conjugates(ADCs)are commonly heterogeneous and require extensive assessment of exposure-efficacy and exposure-safety relationships in preclinical and clinical studies.In this study,we report the generati...; 关键词：Monomethyl auristatin E Antibody-drug conjugates PHARMACOKINETICS Trophoblast cell surface antigen 2

A Survey of Voltage-Controlled-Oscillator-Based ?∑ ADCs被引量：1: 《Tsinghua Science and Technology》2022年第3期472-480,共9页Yi Zhong Nan Sun; This work was supported by the National Natural Science Foundation of China (Nos. 61934009 and 62090042);Beijing National Research Center for Information Science and Technology, Beijing Innovation Center for Future Chips (ICFC);the Academician Expert Open Fund of Beijing Smart-chip Microelectronics Technology Co., Ltd.; The benefits of technology scaling have fueled interest in realizing time-domain oversampling(?∑) of Analog-to-Digital Converters(ADCs). Voltage-Controlled Oscillators(VCO) are increasingly used to design ?∑ADCs bec...; 关键词：Voltage-Controlled Oscillator(VCO) Analog-to-Digital Converter(ADC) oversampling(?∑)ADC time-domain signal processing VCO-based?∑ADC

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