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Systematic Discovery and Pathway Analyses of Metabolic Disturbance in COVID-19
《Infectious Diseases & Immunity》2021年第2期74-85,共12页Bo-Wen Li Xing Fan Wen-Jing Cao He Tian Si-Yu Wang Ji-Yuan Zhang Sin Man Lam Jin-Wen Song Chao Zhang Shao-Hua Zhang Zhe Xu Ruo-Nan Xu Jun-Liang Fu Lei Huang Tian-Jun Jiang Ming Shi Fu-Sheng Wang Guang-Hou Shui 
This work was supported by grants from the Youth Talent Lifting Project(2020-JCJQ-QT-034);the National Science and Technology Major Project of the Ministry of Science and Technology of China(2017ZX10202102-004-002).
Background:The ongoing global coronavirus disease 2019(COVID-19)pandemic is posing a serious public health threat to nations worldwide.Understanding the pathogenesis of the disease and host immune responses will facil...
关键词：COVID-19 Functional metabolites Host immune response Metabolomics Pathway analysis 
Fabrication and performance analyses of 45#steel supports using liquid forging被引量：1
《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》2020年第11期908-922,共15页Yong-gen SUN Yu-shi QI Jiao LI Zhi-ming DU Li-li CHEN Li-hua CHEN 
Project supported by the International Cooperation Project of the Ministry of Science and Technology of China(No.2014DFR50320);the National Natural Science Foundation of China(No.51174064)。
In this paper,45#steel supports prepared by liquid forging showed excellent performances and the effects of processing techniques on the development of microstructures and mechanical properties of these steel supports...
关键词：45#steel Liquid forging Numerical simulation Mechanical properties Wear resistance Fracture behavior 
Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome被引量：10
《Genomics, Proteomics & Bioinformatics》2019年第3期229-247,共19页Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng 
supported by the grants of Key Program of the Chinese Academy of Sciences(Grant No.KJZD-EW-L14 awarded to CZ);the National Key R&D Program of China from the Ministry of Science and Technology of China(Grant No.2016YFB0201702 awarded to JX,as well as Grant Nos.2016YFC0901701 and 2018YFC0910700 awarded to XF)
To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy...
关键词：De novo assembly Reference GENOME Variation map PHENOTYPE association Large POPULATION 
Liquid biopsies:DNA methylation analyses in circulating cell-free DNA被引量：4
《Journal of Genetics and Genomics》2018年第4期185-192,共8页Hu Zeng Bo He Chengqi Yi Jinying Peng 
supported by grants from the National Basic Research Program of China(MOST2016YFC0900301 and 2014CB964900);the National Natural Science Foundation of China(No. 91519325);the Beijing Natural Science Foundation (No. 5162012)
Analysis of patient＇s materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potentia...
关键词：Circulating cell-free DNA DNA methylation Cancer detection Biomarkers Methylation analysis methods 
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex被引量：4
《Cell Research》2017年第12期1485-1502,共18页Chunyi Hu Rekha Rai Chenhui Huang Cayla Broton Juanjuan Long Ying Xu Jing Xue Ming Lei Sandy Chang Yong Chen 
This work was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences （XDB08010201） to ML and YC, the Ministry of Science and Technology of China （2013CB910401 to YC,2013CB910402 to NIL）, the National Natural Science Foundation of China （31470737 and 31670748 to YC, 31330040 and 31525007 to ML）, the Basic Research Project of Shanghai Science and Technology Commission （14JC 1407200 to YC）, and NCI （RO1CA129037, RO1CA202816, R21CA200506, and R21CA182280） to SC.
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 het...
关键词：shelterin structure TIN2-TPP 1 TIN2-TRF2 TELOMERES 
Differential expression analyses for single-ce RNA-Seq： old questions on new data被引量：1
《Frontiers of Electrical and Electronic Engineering in China》2016年第4期243-260,共18页Zhun Miao Xuegong Zhang 
Single-cell RNA sequencing （scRNA-seq） is an emerging technology that enables high resolution detection of heterogeneities between ceils. One important application of scRNA-seq data is to detect differential express...
关键词：SINGLE-CELL RNA-SEQ differential expression 
Crystal-field analyses for trivalent lanthanide ions in LiYF_4
《Journal of Rare Earths》2016年第10期1048-1052,共5页程军 闻军 陈永虎 尹民 段昌奎 
Project supported by the National Key Basic Research Program of China(2013CB921800);the National Natural Science Foundation of China(11274299,11374291,11574298,11204292,11404321);the Anhui Provincial Natural Science Foundation(1308085QE75)
Based on the completely parametric crystal-field model, the energy level parameters, including free-ion parameters and crystal-field parameters, obtained by fitting the experimental energy level data sets of Ln^（3＋...
关键词：crystal-field interactions LiYF4 lanthanide ions variation trends g factors rare earths 
Lateral load-carrying capacity analyses of composite shear walls with double steel plates and filled concrete with binding bars被引量：1
《Journal of Central South University》2016年第8期2083-2091,共9页周德源 刘凌飞 朱立猛 
Project(51178333)supported by the National Natural Science Foundation of China;Project(SLDRCE09-D-03)supported by the Ministry of Science and Technology of China
A method is developed to predict the lateral load-carrying capacity of composite shear walls with double steel plates and filled concrete with binding bars(SCBs). Nonlinear finite element models of SCBs were establish...
关键词：composite shear wall double steel plate binding bar lateral load-carrying capacity nonlinear finite element analysis 
Phylotranscriptomic analyses in plants using Betulaceae as an example被引量：3
《Journal of Systematics and Evolution》2015年第5期403-410,共8页Hui Ma Jing Lu Bing-Bing Liu Bing-Bing Duan Xiao-Dong He Jian-quan Liu 
With the advance of next-generation sequencing techniques, phylogenetic analyses based on genomic data are becoming frequent in plants. However, the efficacy of different methods used to retrieve orthologs for phyloge...
关键词：BETULACEAE ORTHOLOG PHYLOGENY transcriptome. 
A Moving Coordinate Numerical Method for Analyses of Electromagneto-Mechanical Coupled Behavior of Structures in a Strong Magnetic Field Aiming at Application to Tokamak Structures被引量：1
《Plasma Science and Technology》2014年第12期1163-1170,共8页李炜昕 袁振圣 陈振茂 
supported by National Magnetic Confinement Fusion Program of China(No.2013GB113005);the National Natural Science Foundation of China(Nos.51277139,11321062);the National 973 Program of China(No.2011CB610303)
Analysis of the electromagneto-mechanical coupling effect contributes greatly to the high accuracy estimation of the EM load of many EM devices, such as a tokamak structure during plasma disruption. This paper present...
关键词：plasma disruption induced eddy current electromagnetic loads electromagneto-mechanical coupling lagrangian method 
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