云南高校图书馆联盟文献共享服务平台- TELOMERES

TELOMERES: 作品数：39被引量：106H指数：5; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：白跃宏更多>>; 相关机构：上海交通大学附属第六人民医院更多>>; 相关期刊：《Science China(Life Sciences)》《Aging Communications》《Science China Chemistry》《Stem Cell Discovery》更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划SA-SIBS优秀人才奖励基金更多>>

Telomeres: The Promise of New Cancer Therapies: 《American Journal of Molecular Biology》2025年第1期88-96,共9页Ruixian Hou Jonathan J. Darrow; Telomeres have been a subject of genetic research since the 1930s. They play a crucial role in cancer biology, as they influence both cellular senescence and genomic stability. In cancer cells, dysfunctional telomeres...; 关键词：TELOMERE Telomerase Inhibition Cancer Detection Cancer Treatment IMMUNOTHERAPY

ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader: 《Protein & Cell》2024年第7期493-511,共19页Chuanle Wang Yan Huang Yue Yang Ruofei Li Yingying Li Hongxin Qiu Jiali Wu Guang Shi Wenbin Ma Zhou Songyang; National Natural Science Foundation(Grant Nos.82271598,81871109,82071587,31930058,32330023 and 32170757);National Key Research and Development Program of China(2018YFA0107003);Guang Dong Basic and Applied Basic Research Foundation(2020A1515010462).; Telomeres are specialized structures at the ends of linear chromosomes that protect genome stability.The telomeric repeat-containing RNA(TERRA)that is transcribed from subtelomeric regions can invade into double-stran...; 关键词：ILF3 RNA:DNA hybrids telomeric R-loops homologous recombination telomeric DNA damage responses

Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair: 《Journal of Molecular Cell Biology》2024年第3期46-60,共15页Katrina N.Estep John W.Tobias Rafael J.Fernandez Brinley M.Beveridge F.Brad Johnson; supported by the NIH(R01HL148821 and F31CA260918);University of Pennsylvania Abramson Cancer Center(Patel Scholar Award);Pennsylvania Department of Health(Health Research Formula Fund).; Although mechanisms of telomere protection are well-defined in differentiated cells,how stem cells sense and respond to telomere dysfunction,in particular telomeric double-strand breaks(DSBs),is poorly characterized.H...; 关键词：TELOMERES TELOMERASE alternative lengthening of telomeres pluripotent stem cells DNA damage double-strand breaks

Short telomeres impede germ cell specification by upregulating MAPK and TGFβsignaling被引量：2: 《Science China(Life Sciences)》2023年第2期324-339,共16页Chenglei Tian Dai Heng Nannan Zhao Linlin Liu Xiaoyan Sheng Jiyu Chen &Lin Liu; supported by China National Key R&D Program(2018YFA0107002,2018YFC1003004);the National Natural Science Foundation of China(32030033,31430052)。; Functional telomeres protect chromosome ends and play important roles in stem cell maintenance and differentiation. Short telomeres negatively impact germ cell development and can contribute to age-associated infertil...; 关键词：TELOMERE primordial germ cell MAPK TGFΒ chromatin accessibility

Telomerase enzyme in aging and cancer: 《Aging Communications》2022年第4期26-29,共4页Cagri Baris Gunec; Telomerase is an enzyme that maintains the length of telomeres at the ends of chromosomes.Telomeres are protective caps at the ends of chromosomes that keep genetic information intact,enable cells to multiply and prov...; 关键词：TELOMERASE ageing CANCER TELOMERES chromosomes DNA OXIDANTS glycation

Telomere and SARS-CoV-2: A Correlation between Them: 《Journal of Biosciences and Medicines》2022年第11期153-164,共12页Alex He; This article briefly reviews the history of coronavirus detection and states the structural characteristics and pathogenesis of the SARS-CoV-2 strain. Following the conclusion that cellular senescence is thought to co...; 关键词：SENESCENCE SARS-CoV-2 TELOMERES STRUCTURE Relationship STRUCTURE Function TELOMERES

Novel TINF2 gene mutation in dyskeratosis congenita with extremely short telomeres:A case report: 《World Journal of Clinical Cases》2022年第33期12440-12446,共7页Verónica Judith Picos-Cárdenas Saúl Armando Beltrán-Ontiveros JoséAlfonso Cruz-Ramos JoséAlfredo Contreras-Gutiérrez Eliakym Arámbula-Meraz Carla Angulo-Rojo Alma Marlene Guadrón-Llanos Emir Adolfo Leal-León Dora María Cedano-Prieto Juan Pablo Meza-Espinoza; BACKGROUND Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin pigmentation.The genetics of dyskeratosis congenita in...; 关键词：Dyskeratosis congenita TINF2 Germline mutation Novel mutation Short telomeres Case report

Research Progress of Parasite Telomerase and Its Interacting Proteins: 《Journal of Biosciences and Medicines》2022年第10期221-230,共10页Kaisong Hu Jiaqi Zhang Jingtong Zheng; Telomerase is a nucleoprotein that contains reverse transcriptase activity. It is reversely transcribed into DNA at the end of its chromosome using its own RNA as a template to ensure the length and stability of telom...; 关键词：TELOMERASE TELOMERES Parasites Research Progress

cGAS guards against chromosome endto-end fusions during mitosis and facilitates replicative senescence被引量：1: 《Protein & Cell》2022年第1期47-64,共18页Xiaocui Li Xiaojuan Li Chen Xie Sihui Cai Mengqiu Li Heping Jin Shu Wu Jun Cui Haiying Liu Yong Zhao; As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identi...; 关键词：cGAS TELOMERES chromosome end-toend fusion DNA damage response non-homologous end joining MITOSIS genome stability

Characterization of tree shrew telomeres and telomerase被引量：1: 《Journal of Genetics and Genomics》2021年第7期631-639,共9页Jian Sun Wenjing Liu Yongbo Guo Hailin Zhang Dewei Jiang Ying Luo Rong Liu Ceshi Chen; supported by the National Key Research and Development Program of China(2018YFC2000400,2020YFA0112300 to C.Chen);National Natural Science Foundation of China(81830087,31771516 to C.Chen);project of Innovative Research Team of Yunnan Province(2019HC005);CAS“light of West China”Program(xbzg-zdsys-201909)。; The use of tree shrews as experimental animals for biomedical research is a new practice.Several recent studies suggest that tree shrews are suitable for studying cancers,including breast cancer,glioblastoma,lung canc...; 关键词：Tree shrews TELOMERE TERT TERC Breast cancer

TELOMERES