Acknowledgements This study is supported by the National Natural Science Foundation of China (No 81072542), the Natural Science Foundation of Jiangsu Province (No BK2011077), and the Research Fund for the Doctoral Program of Higher Education (No 20123237110010), as well as the College Student's Innovative Training Program, located in Jiangsu Province.
Aim: Liguzinediol is a novel derivative of ligustrazine isolated from the traditional Chinese medicine Chuanxiong (Ligusticum wallichii Franch), and produces significant positive inotropic effect in isolated rat he...