BRAIN-DERIVED

作品数:73被引量:370H指数:11
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Trajectory of brain-derived amyloid beta in Alzheimer’s disease:where is it coming from and where is it going?
《Translational Neurodegeneration》2024年第1期478-496,共19页Ni Liu Anaer Haziyihan Wei Zhao Yu Chen Hongbo Chao 
supported by grants from the Startup Fund of Zhengzhou University(32213157);the Key Scientific Research Projects of Colleges and Universities in Henan Province(K20A180031);the Postdoctoral Startup Fund Zhengzhou University(997002);the National Natural Science Foundation of China(52208131).
Alzheimer’s disease(AD)is a progressive neurological disorder that primarily impacts cognitive function.Currently there are no disease-modifying treatments to stop or slow its progression.Recent studies have found th...
关键词:Alzheimer’s disease Amyloid-β Periphery system Immune clearance 
Central nervous system-derived extracellular vesicles:the next generation of neural circulating biomarkers?
《Translational Neurodegeneration》2024年第1期674-691,共18页Rocío del Carmen Bravo-Miana Jone Karmele Arizaga-Echebarria David Otaegui 
funded by the ISCⅢ(PI20/1253)and by the Basque Government through the ELKARTEK call(KK-2021/00009).
The central nervous system(CNS)is integrated by glial and neuronal cells,and both release extracellular vesicles(EVs)that participate in CNS homeostasis.EVs could be one of the best candidates to operate as nanosized ...
关键词:Extracellular vesicles Circulating biomarkers Central nervous system-derived EVs Neural-derived EVs Brain-derived EVs Cerebrospinal fluid EVs Plasma EVs Neurodegenerative diseases 
Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules被引量:3
《Translational Neurodegeneration》2022年第1期161-177,共17页Francesca Natale Salvatore Fusco Claudio Grassi 
Ministero della Salute-Ricerca Corrente 2022 Fondazione Policlinico Universitario A.Gemelli IRCCS.
Neurodegenerative disorders are one of the most common causes of disability and represent 6.3%of the global burden of disease.Among them,Alzheimer’s,Parkinson’s,and Huntington’s diseases cause cognitive decline,rep...
关键词:Extracellular vesicles Neurodegenerative diseases Stem cells Biomarkers Cognitive decline 
Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives被引量:17
《Translational Neurodegeneration》2020年第2期178-188,共11页Yuan Cheng Ding-Yuan Tian Yan-Jiang Wang 
This review was supported by the National Natural Science Foundation of China(grant no.81930028,91749206,81625007 and 31921003).
Alzheimer’s disease(AD)is the most common type of dementia,and no disease-modifying treatments are available to halt or slow its progression.Amyloid-beta(Aβ)is suggested to play a pivotal role in the pathogenesis of...
关键词:Alzheimer's disease BETA-AMYLOID Blood-brain barrier Lymphatic vessel Venous sinus PERIPHERY Liver Kidney Intestine Skin Blood MONOCYTE Enzymes 
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