目的探讨增强人胶质瘤CHG-5细胞内的活化STAT3抑制蛋白(protein inhibitor of activated STAT3,PIAS3)表达对CHG-5细胞增殖及凋亡等生物学效应的影响。方法构建PIAS3真核表达载体pEGFP-N1-PIAS3,使用脂质体法瞬时转染人CHG-5胶质瘤细胞...
This work was supported partly by a grant from the Sichuan Provincial Bureau of Health,China(No.050209)
OBJECTIVE To identify progression-related genes that lead toastrocytoma progression from a low to a high grade by analyzingthe gene expression profiles from different tumor grades,and all-trans retinoic acid-treated a...
BACKGROUND: Although several genetic aberrations and gene expressional changes have been shown to exist in tumors and different grades of astrocytomas, as well as in normal tissues, the gene profiling and genetic pat...