CHRYSOPHANOL

作品数：17被引量：37H指数：3
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相关领域：医药卫生更多>>
相关作者：李利平马丽刘乐贺葵邦周嘉裕更多>>
相关机构：西南交通大学河北医科大学第二医院更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Integrative Medicine》《Science China Chemistry》《China Medical Abstracts(Internal Medicine)》更多>>
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Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation被引量：9
《Acta Pharmaceutica Sinica B》2019年第4期782-793,共12页Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu 
supported by grants from the 111 Project(No.B16047,China);National Natural Science Foundation of China(81473205,81673433,81803521,and 81872860);Major Project of Platform Construction Education Department of Guangdong Province(No.2014GKPT002,China);Special Program for Applied Science and Technology of Guangdong Province(Nos.2015B020232009,2014B020210003 and 2013B090700010,China);National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004,China);Guangzhou Science and Technology Program Project(No.201604020121,China);Medical Scientific Research Foundation of Guangdong Province(No.A2018078,China)
The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., i...
关键词：CHRYSOPHANOL DOXORUBICIN PARylation CARDIOTOXICITY Apoptosis MITOCHONDRIA 
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