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COLLABORATIVE: 作品数：591被引量：702H指数：10; 导出分析报告; 相关领域：自动化与计算机技术更多>>; 相关作者：马长林黄先祥祝碧衡霍鑫红吴昊更多>>; 相关机构：第二炮兵工程学院北京师范大学浙江大学西安外国语大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家教育部博士点基金更多>>

System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice: 《Animal Models and Experimental Medicine》2025年第4期758-770,共13页Iqbal M.Lone Osayd Zohud Kareem Midlej Charles Brenner Fuad A.Iraqi; Israel Cancer Research Foundation;Samuel Waxman Cancer Research Foundation;Core funding from Tel Aviv University。; It is increasingly recognized that young,chow-fed inbred mice poorly model the com-plexity of human carcinogenesis.In humans,age and adiposity are major risk factors for malignancies,but most genetically engineered mo...; 关键词：Aging and intestinal cancer gene identification of aging and cancer gene maping type 2 diabetes and intestinal cancer

The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes: 《Animal Models and Experimental Medicine》2025年第1期126-141,共16页Avia Paz Kareem Midlej Osayd Zohud Iqbal MLone Fuad A.Iraqi; Tel-Aviv University(TAU)。; Background:Over the past few decades,a threefold increase in obesity and type 2 diabetes(T2D)has placed a heavy burden on the health-care system and society.Previous studies have shown correlations between obesity,T2D...; 关键词：collaborative cross mouse DIABETES host genetic background memory impairments OBESITY

Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-Seq approach: 《Animal Models and Experimental Medicine》2024年第1期36-47,共12页Roa'a H.S.Yosief Iqbal M.Lone Aharon Nachshon Heinz Himmelbauer Irit Gat-Viks Fuad A.Iraqi; European Sequencing and Genotyping Institutes(ESGI),Grant/Award Number:075491/Z/04,085906/Z/08/Z and 090532/Z/09/Z;Tel-Aviv University(TAU)。; Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic back-ground.The aim of this study was to search for candidat...; 关键词：aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-SEQ

Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model,cellular platform,and clinical human data被引量：1: 《Animal Models and Experimental Medicine》2023年第6期537-558,共22页Osayd Zohud Iqbal M.Lone Aysar Nashef Fuad A.Iraqi; supported by a core fund from Tel Aviv University and the Department of Oral and Maxillofacial Surgery,Baruch Padeh Medical Center,Poriya,Israel。; Head and neck squamous cell cancer(HNSCC)is a leading global malignancy.Every year,More than 830000 people are diagnosed with HNSCC globally,with more than 430000 fatalities.HNSCC is a deadly diverse malignancy with m...; 关键词：animal models Collaborative Cross mice GENOMICS head and neck squamous cell cancinoma host genetic susceptibility

A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice: 《Animal Models and Experimental Medicine》2023年第4期355-361,共7页Uriel Kaspersky Roei Levy Aysar Nashef Fuad A.Iraqi Yankel Gabet; Israel Science Foundation(ISF),Grant/Award Number:1822/12;Tel Aviv University;Wellcome Trust,Grant/Award Number:101035/Z/13/Z。; Background:Bone microarchitecture is affected by multiple genes,each having a small effect on the external appearance.It is thus challenging to characterize the genes and their specific effect on bone thickness and po...; 关键词：calvarial porosity(%PoV) calvarial thickness(Ca.Th) collaborative cross mouse population diploe HERITABILITY sex effect

High-fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds被引量：4: 《Animal Models and Experimental Medicine》2023年第2期131-145,共15页Iqbal M.Lone Nadav Ben Nun Aya Ghnaim Arne S.Schaefer Yael Houri-Haddad Fuad A.Iraqi; Binational Science Foundation(BSF)grant number 2015077;German Israeli Science Foundation(GIF)grant I-63-410.20-2017;Israeli Science Foundation(ISF)grant 1085/18;core fund from Tel Aviv University。; Background:Type 2 diabetes(T2D)is an adult-onset and obese form of diabetes caused by an interplay between genetic,epigenetic,and environmental components.Here,we have assessed a cohort of 11 genetically different col...; 关键词：collaborative cross genetic covariance HERITABILITY high-fat diet machine learning mouse model OBESITY type 2 diabetes

Novel spontaneous myelodysplastic syndrome mouse model被引量：2: 《Animal Models and Experimental Medicine》2021年第2期169-180,I0002,共13页Weisha Li Lin Cao Mengyuan Li Xingjiu Yang Wenlong Zhang Zhiqi Song Xinpei Wang Lingyan Zhang Grant Morahan Chuan Qin Ran Gao; National Science and Technology Major Project,Grant/Award Number:2017ZX10304402;Peking Union Medical College,Grant/Award Number:3332020050。; Background:Myelodysplastic syndrome(MDS)is a group of disorders involving he-mopoietic dysfunction leading to leukemia.Although recently progress has been made in identifying underlying genetic mutations,many question...; 关键词：myelodysplastic syndrome(MDS) spontaneous mouse model The Collaborative Cross Mice

Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high-fat diet using the collaborative cross mouse model被引量：5: 《Animal Models and Experimental Medicine》2020年第2期152-159,共8页Luna Karkar Hanifa JAbu-Toamih Atamni Asal Milhem Yael Houri-Haddad Fuad A.Iraqi; Israeli Science Foundation (ISF),Grant/Award Number 1085/18;German Israeli Science Foundation (GIF),Grant/Award Number I-63-410.20-2017;Binational Science Foundation (BSF),Grant/Award Number 2015077;Tel-Aviv University; Background: Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes(T2 D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically ...; 关键词：collaborative cross(CC)mouse model high-fat diet(HFD) mixed oral bacteria(PG and Fn) OBESITY sex-differences type 2 diabetes(T2D)

Efficient protocols and methods for high-throughput utilization of the Collaborative Cross mouse model for dissecting the genetic basis of complex traits: 《Animal Models and Experimental Medicine》2019年第3期137-149,共13页Hanifa J.Abu-Toamih Atamni Fuad A.Iraqi; Hendrech and Eiran Gotwert Fund;Wellcome, Grant/Award Number: 085906/Z/08/Z, 075491/Z/04 and 090532/Z/09/Z;Tel-Aviv University;Israeli Science foundation, Grant/Award Number: 429/09, 961/15 and 1085/18;Binational Science Foundation, Grant/Award Number: 2015077;German Israeli Science Foundation, Grant/Award Number: I-63-410.20-2017;Israeli Cancer Research Fund;Cancer Research Counsel-UK; Cancer Biology Research Center; The Collaborative Cross(CC)mouse model is a next‐generation mouse genetic reference population(GRP)designated for a high‐resolution quantitative trait loci(QTL)mapping of complex traits during health and disease.The...; 关键词：COLLABORATIVE Cross(CC)mouse model complex traits genetic reference population(GRP) infectious and chronic diseases quantitative TRAIT loci(QTL)

Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice被引量：4: 《Animal Models and Experimental Medicine》2018年第3期212-220,共9页Hanifa J.Abu-Toamih Atamni Maya Botzman Richard Mott Irit Gat-Viks Fuad A.Iraqi; Israeli Centers of Research Excellence;Wellcome Trust,Grant/Award Number:085906/Z/08/Z,075491/Z/04,090532/Z/09/Z;Edmond J.Safra Center for Bioinformatics at Tel-Aviv University;Tel-Aviv University; Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role cand...; 关键词：candidate genes COLLABORATIVE CROSS MOUSE model high genetic diverse MOUSE population liver weight quantitative TRAIT locus MAPPING standard RODENT diet

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