COLORECTAL_CANCER

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Heterogeneity of immune infiltration and immunotherapy in colorectal cancer
《Gastroenterology Report》2024年第1期860-861,共2页Yichen Li Jun Hu Min Zhi 
supported by the Sun Yat-sen University Clinical Research 5010 Program[2014008];the National Natural Science Foundation of China[82270544(M.Z.)]and[81600419(J.H.)];the program of Guangdong Provincial Clinical Research Center for Digestive Diseases[2020B1111170004].
Wu et al.[1]recently published a study on potential prognostic and therapeutic values of immune cell infiltration(ICI)subtypes in colorectal cancer(CRC).In this study,they creatively designed a new approach combining ...
关键词：prognosis COLORECTAL 
^(18)F-FAPI-42 PET/CT enhances the diagnostic efficacy for peritoneal metastasis of colorectal cancer and guides treatment decisions:an original retrospective study
《Gastroenterology Report》2024年第1期474-484,共11页Xuneng Zhang Rongqin Zhang Qingyang Zheng Zichuan He Bing Lan Yun Zhong Zhichao Huang Wei Fan Hui Wang Keli Yang Zhanwen Zhang Huaiming Wang 
the National Natural Science Foundation of China[grant no.82103084];the Dongguan Science and Technology of Social Development Program[grant no.20231800904303];Z.Z.has received grants from the National Natural Science Foundation of China[no.81901772];the Natural Science Foundation of Guangdong Province[nos 2019A1515011893,2023A1515011300];the State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia&The First People’s Hospital of Kashi Fund[no.SKL-HIDCA-2020-KS2];H.W.has received grants from the Xinjiang Autonomous Region Technology Plan[grant no.2022E02125];The Sixth Affiliated Hospital of Sun Yat-Sen University Clinical Research-1010 Program:1010CG(2022)-08;K.Y.has received grants from the National Natural Science Foundation of China[grant no.82300619];the Science and Technology Projects in Guangzhou[grant no.2023A04J2245].
Background:Colorectal cancer is the third-most common type of cancer.When peritoneal metastasis(PM)develops,diagnosing metastatic lesions is difficult and the prognosis is poor.This study aimed to compare the value of...
关键词：colorectal cancer peritoneal metastasis ^(18)F-FAPI-42 PET/CT PCI 
Colorectal cancer and inulin supplementation:the good,the bad,and the unhelpful
《Gastroenterology Report》2024年第1期610-620,共11页Manon Oliero Ahmed Amine Alaoui Claire McCartney Manuela M.Santos 
supported by grants from the Canadian Institutes of Health Research[CIHR,grant PJT-159775];the Natural Sciences and Engineering Research Council of Canada[NSERC,grant RGPIN-2018-06442]to M.M.S.
The prebiotic inulin has been vaunted for its potential to reduce the risk of colorectal cancer.Inulin fermentation resulting in the production of short-chain fatty acids,primarily butyrate,has been reported to be ass...
关键词：colorectal cancer INULIN prebiotic gut microbiota short-chain fatty acids 
Current status of serum metabolites biomarkers for polyps and colorectal cancer:a systematic review
《Gastroenterology Report》2024年第1期762-771,共10页Maryam Fatimah Abu Bakar Azmawati Mohammed Nawi Siok Fong Chin Suzana Makpol 
The authors are grateful to the Ministry of Higher Education(MOHE),Malaysia,for the allocation of the Fundamental Research Grant Scheme(FRGS),grant number FRGS/1/2021/SKK05/UKM/02/1.
Background:Early detection of colorectal cancer(CRC)is crucial to enhance the disease treatment and prognosis of patients.Colonoscopy remains the gold standard for CRC detection;however,it requires trained personnel w...
关键词：serum biomarker metabolomics colorectal carcinoma colorectal adenoma screening tool 
Testing region selection and prognostic analysis of MLH1 promoter methylation in colorectal cancer in China
《Gastroenterology Report》2024年第1期120-128,共9页Xiaoli Tan Yongzhen Fang Xinjuan Fan Weihao Deng Jinglin Huang Yacheng Cai Jiaxin Zou Zhiting Chen Hanjie Lin Liang Xu Guannan Wang Huanmiao Zhan Shuhui Huang Xinhui Fu 
supported by the National Natural Science Foundation of China[81971999 to X.F.];Science and Technology Achievements Transformation Project of Sun Yat-sen University[88000-18843232 to X.F.];Young Teacher Training Program of Sun Yat-sen University[14YKPY31 to X.F.];China Scholarship Council[201706385049 to X.F.];the program of Guangdong Provincial Clinical Research Center for Digestive Disease[2020B1111170004];National Key Clinical Discipline.
Background:MLH1 promoter methylation analysis is recommended in screening for Lynch syndrome(LS)in patients with MLH1-deficient colorectal cancer(CRC).The study aims to identify specific methylation regions in the MLH...
关键词：CRC MLH1 deficiency MLH1 promoter methylation overall survival 
Integrated analysis of colorectal cancer metastasis identifies characteristics of tumor cell during metastasis
《Gastroenterology Report》2024年第1期258-267,共10页Haoyu Fu Xiaohuan Lu Tiantian Ji Liping Wang Guobin Wang Lin Wang Zheng Wang 
supported by the National Natural Science Foundation of China Programs(81974382,82072068,82173315,82072167 and 82272277);the Technical Innovation Major Foundation Program of Hubei Province(2022BCA013);the National Key R&D Program of China(2022YFC2408100);Hubei Province Science and Technology Innovation Team Project([2022]No.11).
Background:Metastasis is the main cause of death in colorectal cancer(CRC).Metastasis is a sequential and dynamic process,but the development of tumor cells during this process is unclear.In this study,we aimed to rev...
关键词：colorectal cancer METASTASIS single-cell RNA sequencing 
Analysis of actionable gene fusions in a large cohort of Chinese patients with colorectal cancer
《Gastroenterology Report》2024年第1期405-412,共8页Fu-Rong Kou Jian Li Zheng-Hang Wang Ting Xu Juan-Juan Qian En-Li Zhang Li-Jun Zhang Lin Shen Xi-Cheng Wang 
supported by the capital health research and development of special(2022-2-7083).
Background:The prevalence of gene fusion is extremely low in unselected patients with colorectal cancer(CRC).Published data on gene fusions are limited by relatively small sample sizes,with a primary focus on Western ...
关键词：actionable gene fusions colorectal cancer Chinese population 
Identification of immune cell infiltration landscape for predicting prognosis of colorectal cancer被引量：2
《Gastroenterology Report》2023年第1期260-270,共11页Xueqian Wu Jianxia Li Yuanzhe Zhang Yi Cheng Zehua Wu Weixiang Zhan Yanhong Deng 
approved by the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,China(No.2022ZSLYEC-227);Participants did not need informed consent to partici-pate in the study before taking part in this retrospective study.
Background:The tumor microenvironment plays an essential role in the therapeutic response to immunotherapy.It is necessary to identify immune cell infiltration(ICI)subtypes for evaluating prognosis and therapeutic ben...
关键词：colorectal cancer PROGNOSIS immune cell infiltration ICI scores IMMUNOLOGY tumor microenvironment 
Dynamic heterogeneity of colorectal cancer during progression revealed clinical risk-associated cell types and regulations in single-cell resolution and spatial context
《Gastroenterology Report》2023年第1期365-384,共20页Haoxian Ke Zhihao Li Peisi Li Shubiao Ye Junfeng Huang Tuo Hu Chi Zhang Ming Yuan Yuan Chen Xianrui Wu Ping Lan 
supported by the National Key Research and Development Program of China[grant number 2022YFA1304000];the National Natural Science Foundation of China Key Joint Project[grant number U21A20344];the National Natural Science Foundation of China[grant number 81970452];the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases[grant number 2020B1111170004];the Science and Technology Program of Shenzhen,China[grant number JCYJ20190807161807867];the Starting Funding of Faculty from Sun Yat-sen University[grant number 2021276];the Regional Joint Project for Basic and Applied Basic Research Fund of Guangdong Province[grant number 2022A1515111043];the Science and Technology Planning Project of Guangzhou City[grant number 2023A04J01601],and National Key Clinical Discipline.
Background:Tumor heterogeneity is contributed by tumor cells and the microenvironment.Dynamics of tumor heterogeneity during colorectal cancer(CRC)progression have not been elucidated.Methods:Eight single-cell RNA seq...
关键词：colorectal cancer tumor heterogeneity tumor progression single-cell RNA sequencing spatial transcription sequencing 
Effect of BRAF mutation on the prognosis for patients with colorectal cancer undergoing cytoreductive surgery for synchronous peritoneal metastasis
《Gastroenterology Report》2023年第1期492-499,共8页Zhijie Wu Xiusen Qin Yuanxin Zhang Jian Luo Rui Luo Zonglu Cai Hui Wang 
The Sixth Affiliated Hospital,Sun Yat-Sen University Clinical Research 1010 Program[1010CG(2022)-08];Sun Yat-sen University Clinical Reacher 5010 Program[2017008];supported by National Key Clinical Discipline and the program of Guangdong Provincial Clinical Research Center for Digestive Diseases[2020B1111170004].
Background:KRAS/BRAF mutations(mutKRAS/mutBRAF)are unfavorable prognostic factors for colorectal cancer(CRC)metastases to the liver and lungs.However,their effects on the prognosis for patients with synchronous perito...
关键词：colorectal cancer peritoneal metastasis BRAF PROGNOSIS 
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