Supported by Shanghai Pudong New Area Leading Talents Training Program Project,No.PWR12020-02;Shanghai Pudong New Area Excellent Young Medical Talents Training Program Project,No.PWRq2023-40;Shanghai Pudong New Area Health and Family Planning Scientific Research Project,No.PW2022A-91.
BACKGROUND Diabetic nephropathy(DN)is the most frequent chronic microvascular consequence of diabetes,and podocyte injury and malfunction are closely related to the development of DN.Studies have shown that corilagin(...
supported by the National MegaProject for Infectious Disease (2018ZX10301408, China);the National Mega-Project for Significant New Drug Discovery (2018ZX09711003-002-002, China);the National Natural Science Foundation of China (81802019 and 81902075);the Beijing Natural Science Foundation (7184228, China);CAMS Innovation Fund for Medical Sciences (2018-I2M-3-004 and 2020-I2M-2010, China);the Peking Union Medical College Youth Fund (3332016063 and 3332018096, China)。
Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analo...