CYCLINS

作品数：46被引量：186H指数：7
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相关机构：华中科技大学北京师范大学福建省立医院同济医科大学附属同济医院更多>>
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Targeting cell cycle regulators:A new paradigm in cancer therapeutics
《BIOCELL》2024年第12期1639-1666,共28页GARIMA SINGH SONIKA KUMARI SHARMA NEELU MISHRA AASTHA SONI MANSHI KUMARI SAMARENDRA KUMAR SINGH 
Dysregulation of the cell cycle is a molecular hallmark of cancer,which leads to uncontrolled proliferation and self-renewal of neoplastic cells.To maintain this phenotype,cells acquire multiple molecular alterations ...
关键词：CYCLINS Cyclin-dependent kinases TAXANES Cell cycle inhibitors Targeted therapy 
OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility
《Research》2024年第1期455-469,共15页Yinghong Cui Wei Chen Li Du Zuping He 
the grants from the National Nature Science Foundation of China(32170862 and 31872845);Major Scientific and Technological Projects for Collaborative Prevention and Control of Birth Defect in Hunan Province(2019SK1012);Key Grant of Research and Development in Hunan Province(2020DK2002);Developmental Biology and Breeding(2022XKQ0205);Natural Science Foundation of Hunan Province of China(2020JJ5380,2020JJ5383,and 2021JJ40365);a grant from the Shanghai Key Laboratory of Reproductive Medicine.
Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative medicine.Nevertheless,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remai...
关键词：OIP5 APOPTOSIS reversed 
ZMYND10 downregulates cyclins B1 and D1 to arrest cell cycle by trimethylating lysine 9 on histone 3
《Life Research》2021年第4期17-24,共8页Long-Ji Wu Xiang-Ning Zhang Jian Wang Xia Kong Bi-Ying Zheng Jing Huang Hong-Bing Yu Zhi-Wei He 
Guangdong Medical Scientific Research Foundation,Guangdong Provincial Health Commission,China(2018A256 to XZ);from Guangdong Provincial Natural Scientific Foundation(2018A03030739 to JW and XZ);the Key Fostering Program of the Scientific Foundation of Guangdong Medical University,China(2019006 to JW).
The BLU gene coding for zinc finger,MYND-type containing 10(ZMYND10)protein is mapped on chromosomal region 3p21.It is frequently lost in some kinds of cancers due to hypermethylation on its promoter region and identi...
关键词：BLU/ZMYND10 tumor suppression cell cycle arrest CYCLIN trimethylated lysine 9 on histone 3 
Expression analyses of miRNA Up-MIR-843 and its target genes in Ulva prolifera被引量：1
《Acta Oceanologica Sinica》2020年第10期27-34,共8页Juanjuan Yang Dachun Yu Songdong Shen 
Foundation item:The National Key R&D Program of China under contract No.2016YFC1402102;the project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
microRNAs(miRNA)families play a critical role in plant growth,development,and responses to abiotic stress.In this study,we characterized Up-miR-843 and its targets genes in Ulva prolifera responses to nitrogen deprava...
关键词：CYCLINS nitrogen deprivation MICRORNA U.prolifera heat stress 
Cyclins与结直肠癌的研究进展被引量：3
《牡丹江医学院学报》2018年第1期98-100,104,共4页施颖超 沙瑞华 杨浩 董爱莲 孟敏 姜泓羽 
黑龙江省计生委科研课题(2016-386)
细胞周期是细胞生命活动中最重要的过程,而细胞周期蛋白(Cyclins)、细胞周期蛋白依赖性激酶(CDKs)及细胞周期蛋白依赖性激酶抑制剂(CKIs)则在细胞周期的调控中起到了关键作用。细胞周期失调与肿瘤的发生存在密切的关联。Cyclins表达异...
关键词：CYCLINS 结直肠癌 肿瘤治疗 
细胞周期蛋白与胃癌相关性的研究进展被引量：7
《中国临床医学》2016年第3期368-373,共6页康争春 李勃 蔡慧 马立业 
国家自然基金青年科学基金(81402433);中国博士后科学基金(2015T81088)~~
细胞周期蛋白(cyclins)是一类通过cyclins激酶(cyclin dependent kinase,CDK)调控细胞周期进而控制细胞增殖的蛋白家族,分为细胞周期正性调节蛋白和负性调节蛋白,其异常表达与胃癌发生发展密切相关。通过一些细胞信号通路调节cyclins进...
关键词：胃癌 CYCLINS 信号通路 
Probing the Cell Cycle with Flow Cytometry
《Journal of Biomedical Science and Engineering》2014年第9期698-711,共14页George D. Wilson 
Flow cytometry is a versatile technique to study different aspects of the cell cycle from subpopulations of cells to detailed cell kinetic information. In this paper a basic review of cell kinetic parameters is presen...
关键词：Flow CYTOMETRY Cell Cycle DNA Profile BROMODEOXYURIDINE CYCLINS 
Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines被引量：2
《World Journal of Gastroenterology》2014年第3期795-803,共9页Daniele Baiz Barbara Dapas Rossella Farra Bruna Scaggiante Gabriele Pozzato Fabrizio Zanconati Nicola Fiotti Lara Consoloni Sara Chiaretti Gabriele Grassi 
Supported by The "Fondazione Cassa di Risparmio of Trieste;the "Fondazione Benefica Kathleen Foreman Casali of Trieste";the Italian Minister of Instruction,University and Research(MIUR),PRIN 2010-11,No.20109PLMH2(in part)
AIM: To evaluate the effects of the proteasome inhibitor bortezomib (BZB) on E2Fs and related genes in hepatocellular carcinoma (HCC) cells.
关键词：BORTEZOMIB CYCLINS E2F family Hepatocellular carcinoma Liver MICROARRAY 26S proteasome 
Regulation of the cell cycle via mitochondrial gene expression and energy metabolism in HeLa cells被引量：5
《Acta Biochimica et Biophysica Sinica》2012年第4期347-358,共12页Wei Xiong Yang Jiao Weiwei Huang Mingxing Ma Min Yu Qinghua Cui Deyong Tan 
This work was supported by grants from the National Natural Science Foundation of China （Nos. 30760057, 30960091, and 31160237）, Science ＆ Technological Key Project of Yunnan Province （Nos. 2008CC003, 2008CD069, and 2011C1）, and Specialized Research Fund for the Doctoral Program of Higher Education of China （No. 20115301120009）.
Human cervical cancer HeLa cells have functional mitochondria. Recent studies have suggested that mitochondrial metabolism plays an essential role in tumor cell proliferation. Nevertheless, how cells coordinate mitoch...
关键词：mitochondrial DNA content mitochondrialgene expression mitochondrial membrane potential adenosine triphosphate cell cycle CYCLINS 
Negative regulation of cyclin D3 expression by trans- cription factor c-Etsl in umbilical cord hematopoietic cells
《Acta Pharmacologica Sinica》2011年第9期1159-1164,共6页Fan-kai MENG Han-ying SUN Xi-you TAN Chun-rui LI Jian-feng ZHOU Wen-li LIU 
Aim： To investigate the role of transcription factor c-Etsl in cyclin D3 expression and its effects on the proliferation of umbilical cord hematopoietic cells. Methods： Cyclin D3 promoter deletion constructs were ge...
关键词：transcription factor c-Etsl CYCLINS hematopoietic stem cells CD34~ cells gene regulation cell cycle point mutation 
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