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DNA_DAMAGE: 作品数：397被引量：1149H指数：14; 导出分析报告; 相关作者：黄百渠张瑜刘松陆军孙晋渊更多>>; 相关机构：东北师范大学首都师范大学上海交通大学医学院附属新华医院浙江林学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金中国博士后科学基金更多>>

Comparison of ART outcomes in men with altered mRNA protamine 1/protamine 2 ratio undergoing intracytoplasmic sperm injection with ejaculated and testicular spermatozoa被引量：6: 《Asian Journal of Andrology》2020年第6期623-628,共6页Jonas Sarasa Maria Enciso Laura Garcia Andrea Leza Klaus Steger Jon Aizpurua; The authors thank all the patients for consenting to participate in this study.Furthermore,the technical assistance of Barbara Frohlich and Mareike Buch-Heberling is gratefully acknowledged.KS was supported by a Research Grant from the University Medical Center Giessen and Marburg(UKGM,project 29/2015GI).This research did not receive any other specific grant from funding agencies in the public,commercial,or not-for-profit sectors.; Assisted reproductive technologies invoIving the use of spermatozoa and eggs for in vitro fertilization(IVF)have come as the solution for many infertile couples to become parents.However,in some cases,the use of ejacu...; 关键词：DNA damage male infertility mRNA protamine ratio sperm chromatin testicular spermatozoa

Distribution of DNA damage in the human sperm nucleus:implications of the architecture of the sperm head被引量：1: 《Asian Journal of Andrology》2020年第4期401-408,共8页Silvia González-Rojo Cristina Fernández-Díez Marta Lombó María Paz Herráez; the Spanish Ministry of Economy and Competitiveness(project AGL2011-27787,AGL2014-53167-C3-3-R);Junta de Castilla y Leon(Spain)(EDU/1083/2013)and Fondo Social Europeo.; The sperm nucleus is prone to sustain DNA damage before and after ejaculation.Distribution of the damage is not homogeneous,and the factors determining differential sensitivity among nuclear regions have not yet been ...; 关键词：biomarkers DNA damage human sperm oxidative stress sperm chromatin sperm quality

Sperm DNA damage has a negative effect on early embryonic development following in vitro fertilization被引量：19: 《Asian Journal of Andrology》2018年第1期75-79,共5页Wei-Wei Zheng Ge Song Qi-Ling Wang Shan-Wen Liu Xiao-Li Zhu Shun-Mei Deng An Zhong Yu-Mei Tan Ying Tan; Sperm DNA damage is recognized as an important biomarker of male infertility. To investigate this, sperm DNA damage was assessed by the sperm chromatin dispersion （SCD） test in semen and motile spermatozoa harvested...; 关键词：DNA damage in vitro fertilization pregnancy outcome SPERM

Sertraline-induced reproductive toxicity in male rats： evaluation of possible underlying mechanisms被引量：4: 《Asian Journal of Andrology》2017年第6期672-679,共8页Ozlem Atli Merve Baysal Gozde Aydogan-Kilic Volkan Kilic Seyda Ucarcan Burak Karaduman Sinem Ilgin; This study was conducted to clarify the toxic effects of sertraline （SRT） on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and ...; 关键词：DNA damage oxidative stress reproductive toxicity SERTRALINE

Oxidative stress and male reproductive health被引量：50: 《Asian Journal of Andrology》2014年第1期31-38,共8页Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis; One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to ...; 关键词：DNA damage oxidative stress oxoguanine glycosylase 1 OOCYTE SPERMATOZOA

Is thioredoxin reductase involved in the defense againsi DNA fragmentation in varicocele？被引量：1: 《Asian Journal of Andrology》2013年第4期518-522,I0009,共6页Gill Ozdemirler Erata Canan Kfiqiikgergin Giilsan Aktan Ates KadoOuI Miijdat Uysal Necla Kocak-Toker; We aimed to investigate the role of thioredoxin reductase （TR） and inducible heat shock protein 70 （iHsp70） and their relationship with sperm quality in varicocele （VAR） patients. Semen samples were obtained fro...; 关键词：DNA damage inducible heat shock protein 70 （iHsp70） thioredoxin reductase （TR） SPERMATOZOA VARICOCELE

DNA damage, NF-κB and accelerated aging被引量：1: 《Asian Journal of Andrology》2012年第6期811-812,共2页David G Le Couteur David J Handelsman; The aging process is the major risk factor for disease and disability yet the cel- lular mechanisms for aging are uncertain.

Chronic stress induces ageing-associated degeneration in rat Leydig cells被引量：4: 《Asian Journal of Andrology》2012年第4期643-648,共6页Fei-Fei Wang Qian Wang Yong Chen Qiang Lin Hui-Bao Gao Ping Zhang; Several studies have suggested that stress and ageing exert inhibitory effects on rat Leydig cells. In a pattern similar to the normal process of Leydig cell ageing, stress-mediated increases in glucocorticoid levels ...; 关键词：Ageing chronic stress DNA damage Leydig cells reactive oxygen species

Comparison of four methods to evaluate sperm DNA integrity between mouse caput and cauda epididymidis被引量：2: 《Asian Journal of Andrology》2012年第2期335-337,共3页Serafin Perez-Cerezales： Alberto Miranda Alfonso Gutierrez-Adan; It is well known that transit through the epididymis involves an increase in the compaction of sperm chromatin, which acquires fully condensed status at the caput epididymidis. The purpose of this study was to compare...; 关键词：DNA damage mouse epididymis sperm chromatin sperm maturation the comet assay the sperm chromatin dispersion test the sperm chromatin structure assay TUNEL

The ability of sperm selection techniques to remove single- or double-strand DNA damage被引量：2: 《Asian Journal of Andrology》2011年第5期764-768,共5页Maria Enciso Miriam Iglesias Isabel Galan Jonas Sarasa Antonio Gosalvez Jaime Gosalvez; A wide variety of techniques for the preparation of sperm are currently available, of which the most commonly employed are densitygradient centrifugation （DGC） and swim-up （SUP）. To date, these methods appear to b...; 关键词：density-gradient centrifugation male factor sperm chromatin dispersion sperm DNA fragmentation SWIM-UP

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