FLUORESCENCE

作品数：1389被引量：1995H指数：14
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NIR-Ⅱ fluorescence visualization of ultrasound-induced blood–brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles被引量：5
《Science Bulletin》2022年第22期2316-2326,共11页Simin Liang Dehong Hu Guofeng Li Duyang Gao Fei Li Hairong Zheng Min Pan Zonghai Sheng 
supported by the National Natural Science Foundation of China (92159304, 82171958, 81901812, 81971638, 91859117, 82027803, and 81927807);CAS Key Laboratory of Health Informatics (2011DP173015);the Science and Technology Key Project of Shenzhen(JCYJ20190812163614809, JCYJ20200109114612308, JCYJ2021032 4120011030, JCYJ20190809105207439, JCYJ20220531091408019, and JCYJ20200109114825064);Guangdong Basic and Applied Basic Research Fund (2020A1515110011, 2020A1515010395, and 2022A1515010384);Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province (2020B1212060051);the Key Technology and Equipment R&D Program of Major Science and Technology Infrastructure of Shenzhen (202100102, 202100104);Discipline Construction Project of Guangdong Medical University (4SG21017G)
Focused ultrasound(FUS)-induced blood–brain barrier(BBB) opening is crucial for enhancing glioblastoma(GBM) therapies. However, an in vivo imaging approach with a high spatial–temporal resolution to monitor the BBB ...
关键词：NIR-II fluorescence imaging ULTRASOUND Blood-brain barrier Brain tumor Photothermal therapy 
Fluorescent probes for the detection of disease-associated biomarkers被引量：10
《Science Bulletin》2022年第8期853-878,M0004,共27页Wei-Tao Dou Hai-Hao Han Adam C.Sedgwick Guo-Biao Zhu Yi Zang Xin-Rong Yang Juyoung Yoon Tony D.James Jia Li Xiao-Peng He 
the National Natural Science Foundation of China(21788102,91853201);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX03);the International Cooperation Program of Shanghai Science and Technology Committee(17520750100);the Projects from the Shanghai Science and Techonology Commission(19441905000);the Fundamental Research Funds for the Central Universities(222201717003);the Programme of Introducing Talents of Discipline to Universities(B16017)for financial support;the National Natural Science Foundation of China(22107028);National Postdoctoral Program for Innovative Talents(BX20190115);Shanghai Post-doctoral Excellence Program(2019044);China Postdoctoral Science Foundation(2020M681206)for financial support;the Project funded by China Postdoctoral Science Foundation(2020M681196);the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering,Henan Normal University for support(2020ZD01)。
Fluorescent probes have emerged as indispensable chemical tools to the field of chemical biology and medicine.The ability to detect intracellular species and monitor physiological processes has not only advanced our k...
关键词：Fluorescent probes Fluorescence imaging Biomarker detection Chemical biology 
A metabolic acidity-activatable calcium phosphate probe with fluorescence signal amplification capabilities for non-invasive imaging of tumor malignancy被引量：5
《Science Bulletin》2022年第3期288-298,共11页Qian Jia Ruili Zhang Yongdong Wang Haohao Yan Zheng Li Yanbin Feng Yu Ji Zuo Yang Yang Yang Kanyi Pu Zhongliang Wang 
the National Key Research and Development Program of China(2017YFC1309100,2017YFA0205200,and 2020YFA0211100);National Natural Science Foundation of China(81671753,91959124,21804104,32071406,51922077,and 51872205);China Postdoctoral Science Foundation(2019M650259);the Youth Innovation Team of Shaanxi Universities;Natural Science Foundation of Shaanxi Province of China(2020PT-020);the Fundamental Research Funds for the Central Universities(JB211202,and JC2112);the Open Project Program of the State Key Laboratory of Cancer Biology(Fourth Military Medical University)(CBSKL2019ZDKF06);the Foundation of National Facility for Translational Medicine(Shanghai)(TMSK2020-012);Young Talents Program,and Shanghai Municipal Commission of Health and Family Planning Foundation(2017YQ050)。
Dysregulated energy metabolism has recently been recognized as an emerging hallmark of cancer.Tumor cells,which are characterized by abnormal glycolysis,exhibit a lower extracellular pH(6.5–7.0)than nor-mal tissues(...
关键词：Calcium phosphate Activatable probe Cancer imaging Tumor microenvironment Tumor metabolism 
Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses
《Science Bulletin》2019年第24期1902-1909,共8页Wei-Tao Dou Zhao-Yang Qin Jun Li Dong-Ming Zhou Xiao-Peng He 
supported by the National Natural Science Foundation of China (21788102,91853201,21722801,21776078);the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03);the National Postdoctoral Program for Innovative Talents (BX20190115)
Infection and dissemination of influenza viruses(IVs) causes serious health concerns worldwide.However, effective tools for the accurate detection and blocking of IVs remain elusive. Here, we develop a new sialyllacto...
关键词：Vibration-induced emission Influenza viruses RATIOMETRIC FLUORESCENCE Glycoprobe 
Hierarchically spacing DNA probes on bio-based nanocrystal for spatial detection requirements被引量：2
《Science Bulletin》2019年第13期934-940,共7页Lin Gan Ya Wang Meng Zhang Xuehuan Xia Jin Huang 
financially supported by the National Natural Science Foundation of China (51603171 and 51373131);Talent Project of Southwest University (SWU115034);Fundamental Research Funds for the Central Universities (XDJK2016C032);Key Laboratory of Polymeric Composite & Functional Materials of Ministry of Education (PCFM201605);Hubei Key Laboratory of Advanced Textile Materials & Application (Fzxcl2017003)
Sterically spacing and locating functional matters at the nanoscale exert critical effects on their application,especially for the fluorescence probes whose aggregation causes emission quenching.Here we achieved a hie...
关键词：CELLULOSE nanocrystal DNA FLUORESCENCE probe STERIC SPACING Surface modification MERCURY ion DETECTION 
Molecular imaging of enzyme activity in vivo using activatable probes被引量：4
《Science Bulletin》2016年第21期1672-1679,共8页Runqi Yan Deju Ye 
Acknowledgments This work was supported by the National Natural Science Foundation of China （21505070, 21632008） and Natural Foundation of Jiangsu Province （BK20150567）.
Precise measurement of enzyme activity in living systems with molecular imaging probes is becoming an important technique to unravel the functional roles of different enzymes in biological processes. Recent progress h...
关键词：Activatable probe - Molecular imaging -Enzyme - In vivo . Fluorescence 
Sensitive detection of dopamine and quinone drugs based on the quenching of the fluorescence of carbon dots被引量：4
《Science Bulletin》2016年第20期1615-1623,共9页Xiangling Ren Jiejie Ge Xianwei Meng Xiaozhong Qiu Jun Ren Fangqiong Tang 
supported by the National Natural Science Foundation of China (61178035,61571426,61671435,81671845,81630053,51428301,and 31572343);the National High Technology R&D Program of China (2015BAI23H01);Beijing Natural Science Foundation (4161003)
In this work,we demonstrated that the quinone structure can quench the fluorescence of the carbon dots(CDs).The sensitive determination of dopamine(DA) was studied primarily based on this principle.DA would be transfo...
关键词：Carbon dots Quinone structure Detection DOPAMINE Quinone drugs 
In vivo rapid fluorescence imaging of Alzheimer's disease through accurate target bio-marking of zinc gluconate被引量：3
《Science Bulletin》2015年第16期1465-1467,共3页Lanmei Lai Chunqiu Zhao Meina Su Jing Ye Hui Jiang Xuemei Wang 
supported by the National Natural Science Foundation of China(81325011);the National High Technology Research and Development Program of China(2015AA020502,2012AA022703);the Major Science and Technology Project of Suzhou(ZXY2012028)
Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explored t...
关键词：Zinc gluconate Fluorescence bio-imaging Alzheimer＇s disease 
A new gelator based on tetraphenylethylene and diphenylalanine:Gel formation and reversible fluorescence tuning
《Chinese Science Bulletin》2012年第33期4284-4288,共5页SUN Fei ZHANG GuanXin ZHANG DeQing 
supported by the National Natural Science Foundation of China (50973120,21021091);the National Basic Research Program of China (2011CB808401);Chinese Academy of Sciences
A new gelator 1 based on tetraphenylethylene(TPE) and diphenylalanine was designed and synthesized.Compound 1 was non-emissive in solution,but its fluorescence turned on after the formation of gels,due to the aggregat...
关键词：凝胶形成 二苯基 胶凝剂 荧光 可逆 基础 共焦激光扫描显微镜 扫描电子显微镜 
Monitoring p21 mRNA expression in living cell based on molecular beacon fluorescence increasing rate被引量：2
《Chinese Science Bulletin》2008年第3期357-361,共5页TANG HongXing YANG XiaoHai WANG KeMin TAN WeiHong LIU Bin HE LiFang WANG Wei 
the National Key Basic Research Program(Grant No.2002CB513110);the Key Technologies Research Development Program of China(Grant Nos.2003BA310A16and2005EP090026);International Technologies Collaboration Program of China(Grant No.2003DF000039);the National Natural Science Foun-dation of China(Grant Nos.90606003and20475015);Key Project of Hunan Province Technology Plan of China(Grant No.0399Y1006)
Studying the expression level of mRNA in living cells will offer tremendous opportunities for ad-vancement in cell biology research,disease diagnostics,and drug discovery.In this paper,a molecular beacon(MB)specific f...
关键词：P21 mRNA 鼻咽癌 癌细腻 荧光增强率 基因表达 
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