GBA

作品数：262被引量：123H指数：6
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Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis被引量：2
《Translational Neurodegeneration》2022年第1期641-653,共13页Jingxuan Huang Yangfan Cheng Chunyu Li Huifang Shang 
the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYJC18038);the Sichuan Science and Technology Program(Grant No.2021YJ0415);the Science Foundation of Chengdu Science and Technology Bureau(Grant No.2019-YF05-00307-SN).
A growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to ...
关键词：Genetic variants Sleep disorder Rapid-eye-movement behavior disorders GBA LRRK2 
LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease被引量：4
《Translational Neurodegeneration》2022年第1期869-882,共14页Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho 
Tai Hung Fai Charitable Foundation-Edwin S H Leong Research Programme for Parkinson’s Disease;The Henry G.Leong Endowed Professorship in Neurology;The Donation Fund for Neurology Research.
Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP),...
关键词：Parkinson’s disease INTERACTION LRRK2 GBA GCase Mutation AUTOPHAGY Α-SYNUCLEIN 
Cross-talks among GBA mutations,glucocerebrosidase,and a-synuclein in 66/4-associated Parkinson's disease and their targeted therapeutic approaches:a comprehensive review被引量：3
《Translational Neurodegeneration》2021年第1期27-39,共13页Tapan Behl Gagandeep Kaur Ovidiu Fratila Camelia Buhas Claudia Teodora Judea-Pusta Nicoleta Negrut Cristiana Bustea Simona Bungau 
Current therapies for Parkinson's disease(PD)are palliative,of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration.Due to the complication of ...
关键词：Parkinson's disease Glycosylceramidase GLUCOCEREBROSIDASE Gaucher's disease MUTATIONS Α-SYNUCLEIN 
Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants-Let's get even more personal被引量：1
《Translational Neurodegeneration》2020年第4期499-508,共10页Christian U.von Linstow Ziv Gan-Or Patrik Brundin 
P.B.was supported by grants from the National Institutes of Health(1R01DC016519-01,5R21NS 093993-02,1R21 NS 106078-01A1);P.B.received additional awards from Office of the Assistant Secretary of Defense for Health Affairs(Parkinson's Research Program,Award No.W81XWH-17-1-0534);the Peter C.and Emajean Cook Foundation,which are outside but relevant to the submitted work;Z.G.O.was supported by grants from the Michael J.Fox Foundation,the Canadian Consortium on Neurodegeneration in Aging(CCNA),the Canada First Research Excellence Fund(CFREF)from Parkinson Canada,awarded to McGill University for the Healthy Brains for Healthy Lives(HBHL)program.
Parkinson's disease(PD)is characterized by motor deficits and a wide variety of non-motor symptoms.The age of onset,rate of disease progression and the precise profile of motor and non-motor symptoms display considera...
关键词：Parkinson's disease Precision medicine Personalized medicine GLUCOCEREBROSIDASE GCase Leucine-rich repeat kinase-2 Dopamine PD drug trials PD risk variants 
Premotor biomarkers for Parkinson's disease-a promising direction of research被引量：5
《Translational Neurodegeneration》2012年第1期81-91,共11页Brian R Haas Tessandra H Stewart Jing Zhang 
This work was supported by NIH grants AG033398,ES004696-5897,ES007033-6364,ES016873,ES019277,NS057567,and NS062684-6221.
The second most serious neurodegenerative disease is Parkinson’s disease(PD).Over the past several decades,a strong body of evidence suggests that PD can begin years before the hallmark clinical motor symptoms appear...
关键词：Parkinson’s disease Biochemical markers LRRK2 GBA Α-SYNUCLEIN DJ-1 Clinical biomarkers Premotor Neuroimaging parkin CSF 
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