the Guangdong Basic and Applied Basic Research Foundation(2023A1515012657,2024A1515012128);Scientific Research Project of General Universities in Guangdong Province(2022KTSCX046);Zhanjiang Ocean Young Talent Innovation Project(2023E0002,2022E05008);the Fifth-level Research Fund of Guangdong Medical University(4RS23002a,4SG24248G);the Third-level Research Fund of Guangdong Medical University(4RS23002d,4SG22247G);Songshan Lake Medical and Engineering Integration Innovation Project of Guangdong Medical University(4SG22308P)for support.
Herein,we describe a direct route for the synthesis of 3-gem-difluorovinyl lactams through Zn-mediated reductive hydrodehalogenation.Importantly,by using inexpensive deuterium oxide(D_(2)O),the high value-added vicina...
In December 1905,a silent film was screened on Kulangsu Island in Xiamen,Fujian Province,which is the city's first recorded encounter with film,and the beginning of the connection between the city and the film industr...
financial support provided by the National Natural Science Foundation of China(No.22001203).
The incorporation of additional Csp^(3) atoms into candidate drugs may enhance their pharmacological properties.Nevertheless,it remains challenging to construct desired Csp^(3)-Csp^(3) bonds efficiently and practicall...
We thank the National Natural Science Foundation of China(22001233);Zhejiang Provincial Ten Thousand Talent Program(2020R52021)and Zhejiang Normal University for financial support.
Compared to well-established 1,5-HAT of N-centered radicals,the synthetic applications of 1,2-HAT process were scarce due to the high barrier and constrained three-membered transition state.Here,we have developed a no...