Lung cancer remains a significant global health challenge and identifying lung cancer at an early stage is essential for enhancing patient outcomes. The study focuses on developing and optimizing gene expression-based...
supported by the National Natural Science Foundation of China(Grant Nos.32070663,32125009,and 62172325);the National Key R&D Program of China(Grant No.2022YFC3400300);the Fundamental Research Funds for the Central Universities,China(Grant No.xzy012020012);the Natural Science Basic Research Program of Shaanxi,China(Grant No.2021GXLH-Z-098)to Kai Ye and Xaiofei Yang.
Microsatellite instability(MSI)is an indispensable biomarker in cancer immunotherapy.Currently,MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the g...
Background Colorectal cancer(CRC)is the second leading cause of cancer fatalities and the third most common human disease.Identifying molecular subgroups of CRC and treating patients accordingly could result in better...
Acute leukemia is an aggressive disease that has high mortality rates worldwide.The error rate can be as high as 40%when classifying acute leukemia into its subtypes.So,there is an urgent need to support hematologists...
supported by the Shenzhen KQTD Project(No.KQTD20200820113106007);China Scholarship Council(No.201906725017);the Collaborative Education Project of Industry-University cooperation of the Chinese Ministry of Education(No.201902098015);the Teaching Reform Project of Hunan Normal University(No.82);the National Undergraduate Training Program for Innovation(No.202110542004).
Essential proteins play a vital role in biological processes,and the combination of gene expression profiles with Protein-Protein Interaction(PPI)networks can improve the identification of essential proteins.However,g...
Gene expression(GE)classification is a research trend as it has been used to diagnose and prognosis many diseases.Employing machine learning(ML)in the prediction of many diseases based on GE data has been a flourishin...
King Saud University for funding this work through Researchers Supporting Project Number(RSP2022R426),King Saud University,Riyadh,Saudi Arabia.
The current study proposes a novel technique for feature selection by inculcating robustness in the conventional Signal to noise Ratio(SNR).The proposed method utilizes the robust measures of location i.e.,the“Median...
Gene expression data represents a condition matrix where each rowrepresents the gene and the column shows the condition. Micro array used todetect gene expression in lab for thousands of gene at a time. Genes encode p...
Gene expression refers to the process in which the gene information isused in the functional gene product synthesis. They basically encode the proteinswhich in turn dictate the functionality of the cell. The first ste...
This work was supported by the National Natural Sci-ence Foundation of China[Grant Numbers 11501092,11571068];the Special Fund for Key Laboratories of Jilin Province,China[Grant Number 20190201285JC].
With the development of modern science and technology, more and more high-dimensionaldata appear in the application fields. Since the high dimension can potentially increase the com-plexity of the covariance structure...