financially supported by National Key Research and Development Program of China(No.2021YFB3800900);the National Natural Science Foundation of China(Nos.51925305,51833010 and 52203183);Natural Science Foundation of Xiamen,China(No.3502Z202371004);Fundamental Research Funds for the Central Universities(No.20720230004);the talent cultivation project Funds for the Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(No.HRTP-[2022]52)。
Polyethyleneimine(PEI),as a widely used polymer material in the field of gene delivery,has been extensively studied for modification and shielding to reduce its cytotoxicity.However,research aimed at preparing degrada...
This work was financially supported by Science Foundation Ireland(SFI)Principal Investigator Program(No.13/IA/1962);the National Natural Science Foundation of China(Nos.51873179,51903202),and University College Dublin。
Highly branched poiy(β-amino ester)s(HPAEs)have emerged as one type of the most viable non-viral gene delivery vectors,both in vitro and in viva.However,the effects of different branching strategies on the gene trans...
financially supported by the National Basic Research Program(No.2014CB931900);the National Natural Science Foundation of China(No.21090352)
Chirality is a key factor in the biological activity of many biomolecules. Poly(L-lysine)(PLL), a polypeptide synthesized from L-lysine, is one of the mostly used cationic polymers for gene delivery. The effect of...
financially supported by the National Natural Science Foundation of China(Nos.51125014,51233003);the Ministry of Science and Technology of China(2011CB606202)
A disulfide bond containing polypeptide, PolyK6-R8, was designed and prepared by oxidative polymerization between terminal cysteinyl thiol groups of CHK6HC and CR8C. The molar ratio between CHK6HC and CR8C within obta...