GENOMIC

作品数:720被引量:1687H指数:16
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iCatch:a new strategy for capturing large DNA fragments using homing endonucleases
《Acta Biochimica et Biophysica Sinica》2019年第1期97-103,共7页Jingman Wang Anrui Lu Jiakun Liu Weiren Huang Jin Wang Zhiming Cai Guoping Zhao 
the grants from the National Key Basic Research Program of China (973 Program)(No.2014CB745201);the National Natural Science Foundation of China (No.81772737);the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB19040200);the International Cooperation Program of the Chinese Academy of Sciences (No.153D31KYSB20170121);the National Science Foundation Projects of Guangdong Province (No.2017B030301015);the Shenzhen Municipal Government of China (Nos.JCYJ20170413161749433 and JSGG20160301161836370);the Sanming Project of Shenzhen Health and Family Planning Commission (Nos.SZSM201412018 and SZSM201512037);and the High Level University Medical Discipline Construction (No.2016031638).
Natural genetic materials contain many biosynthetic gene clusters encoding potentially valuable natural products,many of which can be used directly without codon optimization or other manipulations.With the developmen...
关键词:GENOMIC CAPTURE HOMING ENDONUCLEASE BIOLOGICAL part HETEROLOGOUS expression 
Novel and favorable genomic regions for spike related traits in a wheat germplasm Pubing 3504 with high grain number per spike under varying environments被引量:5
《Journal of Integrative Agriculture》2017年第11期2386-2401,共16页CHEN Dan WU Xiao-yang WU Kuo ZHANG Jin-peng LIU Wei-hua YANG Xin-ming LI Xiu-quan LU Yu-qing LI Li-hui 
supported by grants from the National Basic Research Program of China(973 Program,2011CB100104);the National High-Tech R&D Program of China(2011AA100101);the National Natural Science Foundation of China(31071416);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences;the National Key Technologies R&D Program of China during the 12th Five-Year Plan period(2013BAD01B02)
Grain number per spike (GNPS) is a major factor in wheat yield breeding. A new wheat germplasm Pubing 3504 shows superior features in spike traits. To elucidate the genetic basis of spike and yield related traits in...
关键词:WHEAT high GNPS germplasm QTL mapping genomic region 
Genetic Analysis of the PKHD1 Gene with Long-rang PCR Sequencing
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第5期758-766,共9页童永清 刘蓓 付朝泓 郑红云 顾剑 刘航 罗洪波 李艳 
supported by grants from the Hubei Provincial Natural Science Foundation of China(No.2010CDB-06903);National Key Basic Research Program of China(“973”Program,No.2012CB526706);the National Natural Science Foundation of China(Nos.81000771 and 81271694)
PKHD1 gene mutations are found responsible for autosomal recessive polycystic kidney disease(ARPKD). However, it is inconvenient to detect the mutations by common polymerase chain reaction(PCR) because the open re...
关键词:sequencing Sequencing recessive screening detecting conclusion applicable mutation genomic digestion 
An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma被引量:1
《Genomics, Proteomics & Bioinformatics》2015年第4期258-270,共13页Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng 
supported by the National Basic Research Program of China from the National Ministry of Science and Technology(973 Program)to YK(Grant No.2011CB504300)and to HC(Grant No.2012CB910800);the National Natural Science Foundation of China(Grant No.30930102)to YK;the National High-tech R&D Program of China(863 Program;Grant No.2012AA022502);Key Research Program of the Chinese Academy of Sciences of China(Grant No.KJZD-EW-L06-2)to CZ;the Open Fund of MOE Key Laboratory of Carcinogenesis and Translational Research(Grant No.2014KAIFANG-4)to JB
Esophageal squamous cell carcinoma (ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exon...
关键词:Esophageal squamous cell carcinoma Genomic subtype somatic mutation Copy number alteration Cell cycle deregulation 
Genomic Features and Regulatory Roles of Intermediate-Sized Non-Coding RNAs in Arabidopsis被引量:11
《Molecular Plant》2014年第3期514-527,共14页Yuqiu Wang Xuncheng Wang Wei Deng Xiuduo Fan Ting-Ting Liu Guangming He Runsheng Chen William Terzaghi Danmeng Zhu Xing Wang Deng 
grants from the National Basic Research Program of China (973 Program),the National Natural Science Foundation of China,in part by the Peking-Tsinghua Center for Life Sciences and a grant from the Next-Generation BioGreen 21 Program,Rural Development Administration,Republic of Korea
ABSTRACT Recent advances in genome-wide techniques allowed the identification of thousands of non-coding RNAs with various sizes in eukaryotes, some of which have further been shown to serve important functions in man...
关键词:intermediate-sized non-coding RNAs ARABIDOPSIS RNomics. 
Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA被引量:1
《Protein & Cell》2012年第12期943-949,共7页Wei Li Xinlu Wang Guangxia Gao 
supported in part by Grants(to G.G.)from National Natural Science Foundation of China(Grant Nos.81030030,81101262 and 81028011);the National Basic Research Program(973 Program)(No.2012CB910203).
Murine leukemia virus(MLV)-based retroviral vectors is widely used for gene transfer and basic research,and production of high-titer retroviral vectors is very important.Here we report that expression of the Y-box bin...
关键词:Y-box binding protein 1 retroviral vector RNA stability 
Genomic basis for light control of plant development被引量:12
《Protein & Cell》2012年第2期106-116,共11页Jigang Li William Terzaghi Xing Wang Deng 
the National Basic Research Program of China(973 Program)(Grant No.2012CB910900);National Institutes of Health of the USA(GM47850);the National Science Foundation(NSF)Plant Genome Program of the USA(DBI0922604);the Ministry of Agriculture of China(No.2010ZX08010-003).
Light is one of the key environmental signals regulating plant growth and development.Therefore,understanding the mechanisms by which light controls plant development has long been of great interest to plant biologist...
关键词:light control of plant development PHOTOMORPHOGENESIS gene expression epigenomic regulation transcription factors 
In silico Detection of Novel MicroRNAs Genes in Soybean Genome被引量:3
《Agricultural Sciences in China》2011年第9期1336-1345,共10页LIU Yong-xin CHANG Wei HAN Ying-peng ZOU Quan GUO Mao-zu LI Wen-bin 
supported by the National High-Tech R&D Program of China (863 Program, 2006AA100104-4);the 948 Project, Ministry of Agriculture, China (2006-G5);the National Natural Science Foundation of China (30971810, 60932008);the National Basic Research Program of China (973 Program, 2009CB118400);the National Genetically Modified Organisms Breeding Major Projects of China (2009ZX08009-088B);the Postdoctoral Fund in Heilongjiang Province, China (LBH-Z07228);the Technology Project of Ministry of Education, Heilongjiang Province, China (11541025);the Technology Project of Harbin, China (2009RFQXN085)
The importance of microRNAs (miRNAs) at the post-transcriptional regulation level has recently been recognized in both animals and plants. In this study, the simple and most effective method of comparative genomic a...
关键词:soybean genome MICRORNA in sillico comparative genomic approach promoters prediction CLUSTER 
Suppressive Effects of Genomic Imprinted Gene PEG10 on Hydrogen Peroxide-induced Apoptosis in L0_2 Cells被引量:3
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2009年第6期705-709,共5页刘瑶 黄焕军 林菊生 张强 谭锦泉 任精华 
supported by grants from National Natural Sciences Foundation of China (No 30471983, 30872237);Major State Basic Research Development Program of China (973 Program) (No 2007CB512900)
The effects of PEG10 on hydrogen peroxide (H2O2)-induced apoptosis in human normal liver cell line L02 were investigated. The PEG10 gene was transfected into L02 cells by lipofectamine, the positive clone was screen...
关键词:genetic imprinting gene PEG10 L02 hepatocytes hydrogen peroxide apoptosis 
An integrated view of the correlations between genomic and phenomic variables被引量:2
《Journal of Genetics and Genomics》2009年第11期645-651,共7页Dong Yang,Ying Jiang,Fuchu He State Key Laboratory of Proteomics,Beijing Proteome Research Center,Beijing Institute of Radiation Medicine,Beijing 102206,China 
supported by the National Hightech R&D Program (863 Program) (No. 2006AA02A308);the National Basic Research Program of China (973 Program) (No. 2006CB910401, 2006CB910801 and 2006CB910600);the National Natural Science Foundation of China (No. 30700988 and 30700356);the National Natural Science Foundation of China for Creative Research Groups (No. 30621063);the Chinese State Key Project Specialized for Infectious Diseases (No. 2008ZX10002-016, 2009ZX10004-103 and 2009ZX09301002);supported by the State Key Laboratory of Proteomics (No. SKLP-Y200801)
Genome sequencing opened the flood gate of "-omics" studies, among which the research about correlations between genomic and phenomic variables is an important part. With the development of functional genomics and s...
关键词:genomic variable phenomic variable expression pattern EVOLUTION SELECTION 
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