目的原核表达流感病毒(influenza virus,IV)球状头部结构域HA1基因,优化其诱导表达条件,并进行蛋白纯化,以期获得具有良好免疫原性的IV HA1蛋白。方法将Influenza A virus[A/Saratov/CRIE-250/2017(H3N2)]、Influenza A virus[A/Hebei/F...
Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2019R1A6A1A03033084).
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines.In this study,a strategy called computationally optimized broadly react...
The research described in this study was supported by the National Institute of Allergy and Infectious Diseases(NIAID,No.R56 AI148426-01A1 to M.T.);Cincinnati Children Hospital Medical Center(CCHMC,Innovation Funds 2018-2020,GAP Fund 2020-2021,and Research Innovation and Pilot Grant 2020-2021 to M.T.);the Center for Clinical and Translational Science and Training(CCTST)of the University of Cincinnati College of Medicine(Pilot Collaborative Studies Grant 2018-2019 to M.T.);that was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health(No.UL1TR001425).
Even with implementation of current influenza vaccines,influenza still claims up to 500,000 lives worldwide annually,indicating a need for a better vaccine strategy.We have developed a technology to generate unique S_...