HEPATOCELLULAR_CARCINOMA

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Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRAS^(G12D)
《Military Medical Research》2025年第3期464-466,共3页Qiang Cai Quazi T.H.Shubhra 
supported by the National Natural Science Foundation of China(82271518,81971158,and 81671306);the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCFZ-2022-030);the Guiding Projects of Traditional Chinese Medicine in 2023–2024 by Hubei Provincial Administration of Traditional Chinese Medicine(ZY2023F038).
Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Milit...
关键词：Hepatocellular carcinoma F-box and leucine-rich repeat 6(FBXL6)activation Kirsten rat sarcoma(KRAS)^(G12D)mutation Mitogen-activated protein kinase(MEK)/mammalian target of rapamycin(mTOR)pathway Metastasis 
Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma
《Genes & Diseases》2025年第3期42-45,共4页Jie Li Yuyuan Zhang Jinhai Deng Siyuan Weng Hui Xu Yuhao Ba Anning Zuo Shutong Liu Quan Cheng Jian Zhang Peng Luo Zhen Li Xinwei Han Zaoqu Liu 
supported by the Major Science and Technology projects of Henan Province,China(No.221100310100).
The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accum...
关键词：cep hepatocellular carcinoma hepatocellular carcinoma hcc lactate metabolism IMMUNITY proliferation infiltration immunosuppressive cells remodeling immune microenvironment immunosuppressive microenvironment 
Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma
《Genes & Diseases》2025年第3期463-477,共15页Guichuan Lai Biao Xie Cong Zhang Xiaoni Zhong Jielian Deng Kangjie Li Hui Liu Yuan Zhang Anbin Liu Yi Liu Jie Fan Tianyi Zhou Wei Wang Ailong Huang 
supported by the Science and Technology Research Programme Project of Chongqing Municipal Education Commission of China(No.KJQN202300423);the National Youth Science Foundation Project(China)(No.82204159);the Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine(China)(No.2023MS047);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0150);the Intelligent Medicine Research Project of Chongqing Medical University(No.ZHYX202223).
Immunosubtyping enables the segregation of immune responders from non-responders. However, numerous studies failed to focus on the integration of cellular heterogeneity and immunophenotyping in the prediction of hepat...
关键词：Cellular heterogeneity Drug prediction Hepatocellular carcinoma Immune checkpoint inhibitors Immunosubtyping 
Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT
《Oncology Research》2025年第5期1121-1133,共13页WENYING ZHENG YANYAN SHANG KAI DU AILING LUO LIJUN PEI MEIQI LI GUOPING ZHANG MIN DENG 
supported by the National Natural Science Foundation of China(Nos.81972771,82173062);the Key Areas Project of Education Department of Guangdong Province(No.2021ZDZX2017);the Tertiary Education Scientific Research Project of Guangzhou Municipal Education Bureau(No.202235387);the Guangzhou Science and Technology Project of Guangzhou Municipal Science and Technology Bureau(No.2023A03J0428);the Natural Science Foundation of Guangdong Province,China(No.2024A1515013082);the Guangdong Basic and Applied Basic Research 21 Foundation(No.2021A1515010403).
Background:Alterations in splicing factors contribute to aberrant alternative splicing(AS),which subsequently promotes tumor progression.The splicing factor polypyrimidine tract binding protein 1(PTBP1)has been shown ...
关键词：Hepatocellular carcinoma Alternative splicing PTBP1 MAPT 
Risks of liver cirrhosis,hepatocellular carcinoma,hepatic-related complications,and mortality in patients with type 2 diabetes in Taiwan
《World Journal of Diabetes》2025年第5期202-215,共14页Hua-Fen Chen Yung-Yueh Chang Peter Chen Xiao-Han Shen Chin-Huan Chang Wan-Lun Hsu 
Supported by The Far Eastern Memorial Hospital,No.FEMH-2022-C-015,No.FEMH-2022-C-017 and No.FEMH-2023-C-082.
BACKGROUND Hepatitis B and C and alcoholic liver disease are the principal causes of hepaticrelated morbidity and mortality.However,evidence of the associations between diabetes without the above risk factors and hepa...
关键词：Type 2 diabetes mellitus Liver cirrhosis Hepatocellular carcinoma Hepatic-related complications MORTALITY Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis 
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization
《Hepatobiliary & Pancreatic Diseases International》2025年第2期157-163,共7页Wei-Chen Zhang Ke-Yi Du Song-Feng Yu Xue-E Guo Han-Xi Yu Dong-Yan Wu Cheng Pan Cheng Zhang Jian Wu Li-Fang Bian Lin-Ping Cao Jun Yu 
supported by grants from the National Natural Science Foundation of China(82270682);the Natural Science Foundation of Zhejiang Province(LQ21H030007 and LQ20H30006)。
Background:Transarterial chemoembolization(TACE)based neoadjuvant therapy was proven effective in hepatocellular carcinoma(HCC).Recently,tyrosine kinase inhibitors(TKIs)and immune checkpoint inhibitors(ICIs)also showe...
关键词：Neoadjuvant therapy Hepatocellular carcinoma Major pathologic response Transarterial chemoembolization Tyrosine kinase inhibitors Immune checkpoint inhibitors 
Current status and recent progress of nanomaterials in transcatheter arterial chemoembolization therapy for hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第4期66-78,共13页Jia Sun Hai-Liang Li Wen-Jun Zhou Zeng-Xin Ma Xiao-Pei Huang Cheng Li 
Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the ...
关键词：Transcatheter arterial chemoembolization Hepatocellular carcinoma NANOMATERIALS Drug delivery system CHEMOTHERAPY 
Multidisciplinary tumor board is associated with improved survival in patients with hepatocellular carcinoma after liver transplantation
《World Journal of Clinical Oncology》2025年第4期94-101,共8页Li Zhang Jian Yang Jun-Jie Li Chi-Yi Chen Xiao-Dong Wang Yan Xie Wen-Tao Jiang 
Supported by Natural Science Foundation of Tianjin,No.21JCYBJC01140;Key Project of Tianjin Science and Technology Bureau Applied Basic Research,No.23JCZDJC01200;Key Project of Scientific Research Plan of Tianjin Municipal Education Commission,No.2023YXZD07;Project of Tianjin Science and Technology Bureau Applied Basic Research,No.23JCYBJC01800.
BACKGROUND Hepatocellular carcinoma(HCC)ranks as the sixth most common cancer and the third-leading cause of cancer-related deaths worldwide.The multidisciplinary tumor board(MDTB)has been recognized for improving out...
关键词：Multidisciplinary tumor board Hepatocellular carcinoma Liver transplantation Survival outcomes Retrospective study 
Immune checkpoint inhibitors plus anti-angiogenesis in patients with resected high-risk hepatitis B virus-associated hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2025年第4期116-130,共15页Jian-Lin Lu Yuan Cheng Zi-Ling Xu Gui-Xiang Qian Ming-Tong Wei Wei-Dong Jia 
Supported by the Key Research and Development Projects of Anhui Province,No.202104j07020048;National Key Research and Development Program of China,No.2022YFA1304500.
BACKGROUND Currently,there is a lack of effective adjuvant therapies for patients at high-risk of recurrent hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC)after radical resection.Given the efficacy of a...
关键词：Hepatocellular carcinoma Hepatitis B virus Postoperative adjuvant therapy Immune checkpoint inhibitors ANTIANGIOGENESIS 
Comparing transarterial chemoembolization alone to combined transarterial chemoembolization and radiofrequency ablation in primary hepatocellular carcinoma treatment
《World Journal of Gastrointestinal Oncology》2025年第4期144-152,共9页Jing Fei Li-Wen Qi Yuan Liu Min Shu Wen-Qiang Mo 
BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality worldwide.Transarterial chemoembolization(TACE)combined with percutaneous radiofrequency ablation(RFA)has emerged as a promising t...
关键词：Hepatocellular carcinoma Transarterial chemoembolization Radiofrequency ablation Survival analysis Multimodal therapy Locoregional therapy Synergistic effects 
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