We thank Drs.Li Wu,Hai Qi,and Chen Dong for providing mice and reagents and Dr.Fei Shu for help in Listeria monocytogens infection and adoptive transfer experiments.Y.S.is supported by the joint Peking-Tsinghua Center for Life Sciences and the National Natural Science Foundation of China grants 81621002,31630023,31370878 and 20171312479.X.H.is supported by Ministry of Science and Technology of China National Key Research Projects 2015CB943201,National Natural Science Foundation of China grants 31821003,31725010,81661130161,91642115 and 81571580.
Common y chain cytokines are important for immune memory formation.Among them,the role of IL-2 remains to be fully explored.It has been suggested that this cytokine is critically needed in the late phase of primary CD...
Acknowledgments We are grateful to the staff members at Shanghai Synchrotron Radiation Facility for support in diffraction data collection and other members of our group for helpful discussion. This work was supported by grants from the Ministry of Science and Technology of China (2010CB833601, 2006AA02A313, and 2009ZX09503- 009), the National Natural Science Foundation of China (30730028 and 90713046), and the Chinese Academy of Sciences (KSCX2-YW-R- 107 and SIBS2008002).
Interleukin-2 (IL)-2 signaling plays a pivotal role in the activation of immune responses, and drugs that block this pathway have been shown to be effective for the immunosuppression in patients with organ transplan...