LAFUTIDINE

作品数：8被引量：24H指数：3
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相关期刊：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《World Journal of Gastroenterology》《World Journal of Gastrointestinal Pharmacology and Therapeutics》《World Journal of Gastrointestinal Endoscopy》更多>>
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Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease被引量：2
《World Journal of Gastroenterology》2016年第23期5430-5435,共6页Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita 
Supported by Taiho pharmaceutical co.Ltd
AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD an...
关键词：Gastroesophageal reflux disease Proton pump inhibitors Histamine receptor-2 antagonists Los Angeles classification 
Development and evaluation of lafutidine solid dispersion via hot melt extrusion:Investigating drug-polymer miscibility with advanced characterisation被引量：4
《Asian Journal of Pharmaceutical Sciences》2014年第2期92-106,共15页Ritesh Fule Purnima Amin 
The author is also thankful to UGC(SAP)for providing the research fellowship and Institute of Chemical Technology,ELITE status(Mumbai,India)for providing all facilities and guidance.The authors are thankful to S.A.I.F.department at Indian Institute of Technology,Mumbai for Raman and 1HeCOSY NMR experimental help and analyses.
In current study,immediate release solid dispersion(SD)formulation of antiulcer drug lafutidine(LAFT)was developed using hot melt extrusion(HME)technique.Amphiphilic Soluplusused as a primary solubilizing agent,with ...
关键词：LAFUTIDINE Solid dispersion Hot melt extrusion Dissolution rate Raman spectroscopy Atomic force microscopy 
An open-label,randomized,cross-over bioequivalence study of lafutidine 10 mg under fasting condition
《World Journal of Gastrointestinal Pharmacology and Therapeutics》2010年第5期112-118,共7页Bhupesh Dewan Raghuram Chimata 
AIM:To assess the relative bioavailability and pharmacokinetic properties of two formulations(test and reference) of Lafutidine 10 mg.METHODS:The study was performed as an open label,randomized,two-way,two-period,two-...
关键词：Liquid chromatography/tandem mass spectrometry LAFUTIDINE GASTROPROTECTIVE Pharmacokinetics BIOEQUIVALENCE 
A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers被引量：7
《World Journal of Gastrointestinal Endoscopy》2010年第1期36-40,共5页Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi 
AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all pat...
关键词：CYTOPROTECTION Endoscopic SUBMUCOSAL dissection Gastric ulcer HISTAMINE H2 receptor ANTAGONISTS LAFUTIDINE Proton pump inhibitors RABEPRAZOLE 
Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole被引量：3
《World Journal of Gastroenterology》2008年第15期2406-2410,共5页Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa 
AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. ME...
关键词：LAFUTIDINE LANSOPRAZOLE H2 receptor antagonists Proton pump inhibitors Antisecretory activity 
Improvement in symptoms after H_2-receptor antagonist-based therapy for eradication of H pylori infection被引量：1
《World Journal of Gastroenterology》2007年第28期3836-3840,共5页Takeshi Hagiwara Mototsugu Kato Tomonori Anbo Akimichi Imamura Toshihiro Suga Takumi Uchida Akira Fujinaga Manabu Nakagawa Soichi Nakagawa Yuichi Shimizu Jyunji Yamamoto Hiroshi Takeda Masahiro Asaka 
AIM: To investigate the therapeutic effects of triple therapy combining lafutidine with clarithromycin and amoxicillin on H pylori infection and the resolution of gastroesophageal symptoms after eradication. METHODS: ...
关键词：HPYLORI Gastroesophageal symptoms LAFUTIDINE LANSOPRAZOLE 
Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins被引量：6
《World Journal of Gastroenterology》2006年第19期3031-3037,共7页Kazuhiro Fukushima Yoko Aoi Shinichi Kato Koji Takeuchi 
Supported in part by the Kyoto Pharmaceutical University's "21st Century COE" program and the "Open Research" Program from the Ministry of Education, Science and Culture of Japan
AIM： Lafutidine, a histamine H2 receptor antagonist, exhibits gastro-protective action mediated by capsaicinsensitive afferent neurons （CSN）. We compared the effect between lafutidine and capsaicin, with respect to...
关键词：LAFUTIDINE A histamine H2-receptor antagonist Gastric protection Prostaglandin Capsaicin-sensirive afferent neuron TRPVt 
Separation and identification of cis and trans isomers of 2-butene-1,4-diol and lafutidine by HPLC and LC-MS被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2005年第1期74-78,共5页潘春秀 徐秀珠 何红梅 蔡小军 张雪君 
Project(No.03111)supportedbytheFoundationofAnalysis&MeasurementofZhejiangProvince,China
The cis and trans isomers separation of 2-butene-1,4-diol and lafutidine were studied by HPLC on two kinds of chiral columns: (S,S)-Whelk-O 1 and ChiraSpher. The isomers of 2-butene-1,4-diol can be separated on both c...
关键词：2-butene-1 4-diol LAFUTIDINE Isomers separation (S S)-Whelk-O 1 ChiraSpher LC-MS 
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