financially supported by the National Natural Science Foundation of China (32071391);the Beijing Nova Program (20230484423);the Fundamental Research Funds for the Central Universities (06500230,FRF-BR-23-02B)。
Lipid nanoparticles(LNPs)are non-viral nucleic acid delivery systems that show great potential in vaccine development and disease treatment.Although LNPs are particularly advantageous for in vivo delivery,the wide app...
supported by Chinese Academy of Medical Science Innovation Fund for Medical Sciences(2022-I2M-2-002);the National High-Level Hospital Clinical Research Funding(2022-PUMCH-D-002,China);Clinical and translational medicine research project of the Chinese Academy of Medical Sciences(2022-I2M-C&T-A-008,China),the National Natural Science Foundation of China(82272046);the Fundamental Research Funds for the Central Universities(3332023124,China).
Integrinα_(v)β_(3)is overexpressed in various tumor cells and angiogenesis.To date,no drug has been proven to target it for therapy.A first-in-human study was designed to investigate the safety,pharmacokinetics,and ...