supported by the National Natural Science Foundation of China[81372427 and 81672787(Y.Tao);81271763 and 81672991(S.Liu)];the National Basic Research Program of China[2015CB553903(Y.Tao)]
Ferroptosis, a novel mode of non-apoptotic cell death,involves a metabolic dysfunction that results in the production of iron-dependent reactive oxygen species (ROS),an iron carrier protein (transferrin), intracellula...
supported by grants from the National Natural Science Foundation of China(Grant Nos.81673031,81001031,81372285)
Background: Right upper lobectomy(RUL) for lung cancer with di erent dissecting orders involves the most vari?able anatomical structures, but no studies have analyzed its e ects on postoperative recovery. This study c...
supported by Peking Union Medical College Youth Fund and the Fundamental Research Funds for the Central Universities(No.2017310049)
Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung canc...
supported by two grants from the Research Grants Council of the Hong Kong Special Administrative Region,China(No.CUHK4460/03M and No.CUHK4103/02M)
Background:Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence.However,the effects of these habits on lung cancer prognosis have been studied rarely.The purpose of...
supported by grants from the National Natural Science Foundation of China(Grant 81672758);the Science and Technology Commission of Shanghai Municipality(Grants 16ZR1410400 and 14DZ2270100);the Fundamental Research Funds for the Central Universities(Grant 78260029)
The KRAS gene is frequently mutated in multiple cancer types,but it fell off the drug discovery radar for many years because of its inherent "undruggable" structure and undefined biological properties.As reported in t...
Background: Owing to the use of tobacco and the consumption of alcohol and adulterated food, worldwide cancer incidence is increasing at an alarming and frightening rate. Since the last decade of the twentieth century...
supported by the National High Technology Research and Development Program of China(No.2012AA02A501);the Special Fund for Public Health Trade(No.201202014)
Background:With industrial and economic development in recent decades in South China,cancer incidence may have changed due to the changing lifestyle and environment.However,the trends of lung cancer and the roles of s...
supported by grants from the Ministry of Science and Technology of China(2011CB504304 and 2012CB967003);the National Natural Science Foundation of China(81271902 and 81230045)
Background:Elevated levels of serum C-reactive protein(CRP) have been reported to have prognostic significance in lung cancer patients.This study aimed to further identify CRP-bound components as prognostic markers fo...
supported by China State Twelfth Five-Year Plan Key Project(No.2013ZX09401003);Hangzhou Municipal Key Project(No.2014-1249)
Avitinib,a new generation inhibitor of epidermal growth factor receptor(EGFR),was approved for clinical trial in both China and the United States,and the phase 1 trials were initiated in both countries in parallel.In ...
supported by the Hengrui-US Chinese Anti-Cancer Association (USCACA) Scholarship program
Introduction:Few data have been published comparing early-phase trials for lung cancer between China and the United States(US).This study was to investigate the differences of phase 1 trials for lung cancer between th...