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Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients被引量：2
《World Journal of Gastroenterology》2024年第8期855-862,共8页Li-Hui Wang Bin-Bin Su Sheng-Shu Wang Guan-Chao Sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen 
This study was reviewed and approved by the Ethics Committee of the PLA General Hospital(Ethics audits No.S2022-414-01).
BACKGROUND Reflux esophagitis has an increasing prevalence and complex and diverse symptoms.Identifying its risk factors is crucial to understanding the etiology,prevention,and management of the disease.The occurrence...
关键词：Gastroesophageal reflux ESOPHAGITIS Food intolerance Metabolic syndrome Helicobacter pylori CHEMOKINES 
Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model
《World Journal of Gastroenterology》2024年第5期471-484,共14页Hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu Zheng-Rui Bian Bei-Bei Zhang Qian Yu Yin-Hai Xu Ren-Xian Tang Kui-Yang Zheng Chao Yan 
Supported by the National Natural Science Foundation of China,No.82172297;Natural Science Foundation of Jiangsu Province of China,No.BK20211346 and No.BK20201011;Natural Science Foundation of Jiangsu Higher Education Institutions of China,No.22KJA310007;Xuzhou Science and Technology Project,No.KC22055.
BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment options.Recombinant adeno-associated virus(rAAV)provid...
关键词：Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects INFLAMMATION 
Immune checkpoint inhibitor-mediated colitis is associated with cancer overall survival被引量：1
《World Journal of Gastroenterology》2022年第39期5750-5763,共14页Alexa R Weingarden John Gubatan Sundeep Singh Tatiana Clorice Balabanis Akshar Patel Arpita Sharma Aida Habtezion 
BACKGROUND Immune checkpoint inhibitor-mediated colitis(IMC)is a common adverse event following immune checkpoint inhibitor(ICI)therapy for cancer.IMC has been associated with improved overall survival(OS)and progress...
关键词：Immune checkpoint inhibitors Immune checkpoint inhibitor-mediated colitis Immune-related adverse events 
Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A被引量：2
《World Journal of Gastroenterology》2022年第37期5420-5443,共24页Xian Li Yi-Ru Han Xuefeng Xuefeng Yong-Xiang Ma Guo-Sheng Xing Zhi-Wen Yang Zhen Zhang Lin Shi Xin-Lin Wu 
the National Natural Science Foundation of China,No.81860416 and No.22168028;Inner Mongolia Autonomous Region Grassland Talent Innovation Talent Team Fund,No.2019;Inner Mongolia Natural Science Fund,No.2021MS02005.
BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors worldwide.The identification of novel diagnostic and prognostic biomarkers for CRC is a key research imperative.Immunohistochemical analysis ...
关键词：Colorectal cancer Centromere protein K Bioinformatics analysis Lentivirus-mediated short hairpin RNA interference Cullin 4A 
Role of bile acids in liver diseases mediated by the gut microbiome被引量：10
《World Journal of Gastroenterology》2021年第22期3010-3021,共12页Jun-Wei Shao Tian-Tian Ge Sen-Zhong Chen Gang Wang Qin Yang Chun-Hong Huang Li-Chen Xu Zhi Chen 
Supported by National Science and Technology Major Project of China,No.2018ZX10302206.
The intensive crosstalk between the liver and the intestine performs many essential functions.This crosstalk is important for natural immune surveillance,adaptive immune response regulation and nutrient metabolism and...
关键词：Bile acids Gut microbiome Liver diseases Farnesoid X-activated receptor G protein-coupled bile acid receptor 1 Immune response 
Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway被引量：16
《World Journal of Gastroenterology》2021年第9期815-834,共20页Shang-Qing Huang Yi Wen Hong-Yu Sun Jie Deng Yao-Lei Zhang Qi-Lin Huang Bing Wang Zhu-Lin Luo Li-Jun Tang 
Supported by The National Natural Science Foundation of China,No.81772001;the National Clinical Key Subject of China,No.41732113;
BACKGROUND Our previous studies confirmed that abdominal paracentesis drainage(APD)attenuates intestinal mucosal injury in rats with severe acute pancreatitis(SAP),and improves administration of enteral nutrition in p...
关键词：Abdominal paracentesis drainage Severe acute pancreatitis High mobility group box 1 Toll-like receptor 4 Nuclear factor-κB 
pregnane X receptor and constitutive androstane receptor modulate differently CYp3A-mediated metabolism in earlyand late-stage cholestasis被引量：5
《World Journal of Gastroenterology》2017年第42期7519-7530,共12页Daniela Gabbia Arianna Dalla Pozza Laura Albertoni Roberta Lazzari Giorgia Zigiotto Maria Carrara Vincenzo Baldo Tatjana Baldovin Annarosa Floreani Sara De Martin 
Supported by the University of Padova,No.CPDA138721/13
AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive androstane receptor(CAR).METHODS Cholestasis was induced by bile...
关键词：CHOLESTASIS CYP3A Drug metabolism Pregnane X receptor Constitutive androstane receptor 
Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats被引量：30
《World Journal of Gastroenterology》2017年第13期2330-2336,共7页Yi Wang Ruo-Wu Shen Bing Han Zhen Li Le Xiong Feng-Yu Zhang Bei-Bei Cong Bei Zhang 
Supported by the Natural Science Foundation of Shandong Province,No.2014ZRB01466
AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood m...
关键词：NOTCH Peripheral blood mononuclear cells Concanavalin A Transforming growth factor-β Liver fibrosis 
Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8^+ CD11c^+ cells被引量：3
《World Journal of Gastroenterology》2017年第10期1804-1815,共12页Hai-Mei Zhao Fei Han Rong Xu Xiao-Ying Huang Shao-Min Cheng Min-Fang Huang Hai-Yang Yue Xin Wang Yong Zou Han-Lin Xu Duan-Yong Liu 
Supported by the National Natural Science Foundation of China,No.81260595 and No.81460679;Chinese Scholar-ship Council and Jiangxi Province as visiting scholar,No.201408360106 and No.201408360110;the Traditional Chinese Medicine Project of Health Department of Jiangxi Province,No.2015B049;Jiangxi University of Traditional Chinese Medicine,No.JZYC15S13
AIM To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8(+)CD11c(+) cells. METHODS We evaluated the suppressive effect of Cur on CD8(+)CD11c(+) cells in spleen and Peyer's patches (P...
关键词：CD8 CD11C CURCUMIN Experimental colitis Therapeutic effect 
Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer被引量：7
《World Journal of Gastroenterology》2015年第29期8769-8775,共7页Tsutomu Namikawa Tomoaki Yatabe Keiji Inoue Taro Shuin Kazuhiro Hanazaki 
5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically acc...
关键词：Fluorescence imaging 5-aminolevulinic acid Photodynamic diagnosis Photodynamic therapy Gastric cancer 
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