MITOTIC

作品数:63被引量:108H指数:6
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相关领域:生物学医药卫生更多>>
相关作者:张博周平坤黄琼萍朱学良鄢秀敏更多>>
相关机构:沈阳农业大学军事医学科学院北京大学中国科学院上海生命科学研究院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Epigenetic Enabled Normal Human Cells, Lead to <i>First Cell</i>’s Unique Division System, Driving Tumorigenesis Evolution
《Journal of Cancer Therapy》2022年第1期48-69,共22页Kirsten H. Walen 

Normal cells must become cancer-enabling before anything else occurs, according to latest literature. The goal in this mini-review is to demonstrate special tetraploidy...

关键词:Mitotic Slippage DNA Damage Repair Process 4-Chromatid Chromosomes Diplochromosome Tetraploidy 90°-4n Nucleus Turn G1-Phase-Diploid Cell Arrest Time Reduced Cell Cycle Fitness Increase 
A Traceable Cancer Model: DNA Damage, Fragile Site-SMGs, Mitotic Slippage, 4n-Genome-Reduction to Fitness-Gained, Initiating, 2n First Cells被引量:1
《Journal of Cancer Therapy》2021年第6期365-386,共22页Kirsten H. Walen 
We have known since 1976 that cancer evolves clonally from one initiated normal human cell, the first cell. Today we see that this fact has been ...
关键词:S-Period-DDR 2n-4n-90° Nuclear Turn Cytoskeleton/Cell Polarity Amitosis Time-Short Cell Cycle Fitness-Gain ANEUPLOIDY Loss-of-Function Genetics Parasitic-Tumor Life Therapy-Possibilities 
Cancer Prevention? Fundamental Genomic Alterations Are Present in Preneoplasia, Including Function of High Frequency Selected Mutations (HFSMs)被引量:2
《Journal of Cancer Therapy》2016年第6期416-426,共11页Kirsten H. Walen 
In a series of publications a special, tetraploid diplochromosomal division system to only two types of progeny cells (4n/4C/G1 and 2n/4C para-diploid) has been suggested to initiate preneoplasia that can lead to a ca...
关键词:DNA/Breakage/Repair Mitotic Slippage COHESIN Tetraploid System Segregation/Orderly HYPERPLASIA Dysplasia 4n-Cell-Cycles Skewed Cytoskeleton Antibody CRISPR-Caspase Therapy 
Wound Healing Is a First Response in a Cancerous Pathway: Hyperplasia Developments to 4n Cell Cycling in Dysplasia Linked to Rb-Inactivation被引量:5
《Journal of Cancer Therapy》2015年第10期906-916,共11页Kirsten H. Walen 
In a series of publications, the hypothesis of a special-type of endo-polyploidy, marked by 4-chromatid chromosomes (diplochromosomes), in the initiation of tumorigenesis has been presented from in vitro experiments. ...
关键词:MITOTIC SLIPPAGE Endotetraploidization Diplochromosomes Meiotic-Like Division 4n/4C/G1 PROGENY PROLIFERATIVE Advantage INACTIVATED p53 p16[ink4a] 
Geldanamycin Combination with Colcemid Induces Mitotic Arrest through Stabilization of bubR1 Mitotic Kinase in Human Tumor Cells
《Journal of Cancer Therapy》2013年第3期709-719,共11页Pitke Vikrant Vinay Lebaka Prasanna Anjaneya Reddy Jonnala Ujwal Kumar Sugunan Sreedevi Upasana Sarangi Amere Subbarao Sreedhar 
Mitosis-targeted anti-cancer therapies gained much attention in recent years. However, lack of tumor selectivity poses limitations to the current anti-mitotic drugs to be used as broad-spectrum anti-cancer agents. In ...
关键词:HSP90 GELDANAMYCIN BUBR1 Cell Cycle TUMOR Cells 
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