云南高校图书馆联盟文献共享服务平台- GELDANAMYCIN

GELDANAMYCIN: 作品数：30被引量：103H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王以光甄永苏廖志勇罗红霞张胜华更多>>; 相关机构：中国医学科学院北京协和医学院北京协和医学院重庆医科大学上海医药工业研究院更多>>; 相关期刊：《沈阳药科大学学报》《南方医科大学学报》《Journal of Pharmaceutical Analysis》《Journal of Biophysical Chemistry》更多>>; 相关基金：国家自然科学基金基础研究重大项目前期研究专项重庆医科大学创新基金国家重点基础研究发展计划更多>>

Rational design, synthesis, and biological evaluation of novel C6-modified geldanamycin derivatives as potent Hsp90 inhibitors and anti-tumor agents: 《Chinese Chemical Letters》2023年第2期434-439,共6页Ruxuan Wang Rentao Zhang Haoran Yang Nina Xue Xiaoguang Chen Xiaoming Yu; supported by the CAMS Innovation Fund for Medical Sciences (Nos. CIFMS 2016-I2M-3–009 and CIFMS 2017I2M-3–011);the National Natural Science Foundation of China (No. 21272279)。; Heat shock protein 90(Hsp90) is an appealing anticancer drug target that provoked a tremendous wave of investigations. Geldanamycin(GA) is the first identified Hsp90 inhibitor that exhibited potent anticancer activity...; 关键词：Hsp90 inhibitors Geldanamycin derivatives Total synthesis Structure-activity relationship ANTICANCER

深海链霉菌Streptomyces samsunensis中geldanamycin类抗生素的分离纯化被引量：1: 《中国海洋药物》2020年第2期1-10,共10页董玉静张京星李文利李花月; 国家自然科学基金项目(21502180,31570032,41506157);国家自然科学基金-山东省联合海洋科学研究基金项目(U1706206,U1406403);青岛市民生科技计划项目(17-3-3-44-nsh)资助。; 目的从深海链霉菌Streptomyces samsunensis OUCT16-12中挖掘活性次级代谢产物并进行抗菌活性评价。方法 Streptomyces samsunensis OUCT16-12经过全基因组测序后进行生物信息学分析,通过核磁及质谱等确定2个天然产物(1和2)的结构。结...; 关键词：基因组信息深海链霉菌多重耐药抗生素

Docking of Human Heat Shock Protein 90 with Selenoderivatives of Geldanamycin被引量：1: 《Crystal Structure Theory and Applications》2019年第2期13-27,共15页Jason T. Kilembe Albert S. Lundemba Dikima D. Bibelayi Glodi M. Ndefi Juliette Pradon Zéphyrin G. Yav; The interference of human heat shock protein 90 (HSP90) in many signalling networks associated with cancer progression makes it an important drug target. In the present work, we investigated the binding ability of 9 s...; 关键词：1YET GELDANAMYCIN Selenoderivatives CAMBRIDGE Structural Database BINDING Energy Molecular ELECTROSTATIC Potential (MEP)

Anti-Inflammatory Activity of Geldanamycin and Its Derivatives in LPS-Induced RAW 264.7 Cells: 《Advances in Microbiology》2019年第4期398-421,共24页Thongchai Taechowisan Winyou Puckdee Watcharee Waratchareeyakul Waya S. Phutdhawong; Geldanamycin (1) had been isolated as a major compound from Streptomyces zerumbet W14;an endophyte of Zingiber zerumbet (L.) Smith. Two new geldanamycin derivatives;17-(tryptamine)-17-demethoxygeldanamycin (2) and 17...; 关键词：ANTI-INFLAMMATORY Activity GELDANAMYCIN DERIVATIVES STREPTOMYCES zerumbet RAW 264.7 CELLS

Streptomyces zerumbet, a Novel Species from Zingiber zerumbet(L.) Smith and Isolation of Its Bioactive Compounds被引量：2: 《Advances in Microbiology》2019年第3期194-219,共26页Thongchai Taechowisan Winyou Puckdee Waya S. Phutdhawong; Streptomyces zerumbet W14, a novel species of the endophyte genus Streptomyces was isolated from the rhizome tissue of Zingiber zerumbet (L.) Smith. Identification of strain W14 was based on its morphology, chemotaxon...; 关键词：Antibacterial ACTIVITY Anti-Inflammatory ACTIVITY Endophytic Actinomycetes GELDANAMYCIN Methyl 5-(Hydroxymethyl)Furan-2-Carboxylate ZINGIBER zerumbet

Dissecting the Heat Stress Response in Chlamydomonas by Pharmaceutical and RNAi Approaches Reveals Conserved and Novel Aspects: 《Molecular Plant》2013年第6期1795-1813,共19页Stefan Schmollinger Miriam Schulz-Raffelt Daniela Strenkert Daniel Veyel Olivier Vallon Michael Schroda; To study how conserved fundamental concepts of the heat stress response （HSR） are in photosynthetic eukaryotes, we applied pharmaceutical and antisense/amiRNA approaches to the unicellular green alga Chlamydomonas r...; 关键词：heat shock factor unfolded protein response heat stress response inhibitor feeding Chlamydomonas rein-hardtii HSP90 HSP70 protein folding calcium GELDANAMYCIN canavanine.

Geldanamycin Combination with Colcemid Induces Mitotic Arrest through Stabilization of bubR1 Mitotic Kinase in Human Tumor Cells: 《Journal of Cancer Therapy》2013年第3期709-719,共11页Pitke Vikrant Vinay Lebaka Prasanna Anjaneya Reddy Jonnala Ujwal Kumar Sugunan Sreedevi Upasana Sarangi Amere Subbarao Sreedhar; Mitosis-targeted anti-cancer therapies gained much attention in recent years. However, lack of tumor selectivity poses limitations to the current anti-mitotic drugs to be used as broad-spectrum anti-cancer agents. In ...; 关键词：HSP90 GELDANAMYCIN BUBR1 Cell Cycle TUMOR Cells

Hsp90 and reactive oxygen species regulate thermotolerance of rice seedlings via induction of heat shock factor A2 (OsHSFA2) and galactinol synthase 1 (OsGolS1)被引量：1: 《Agricultural Sciences》2013年第3期154-164,共11页Nong Thi Hue Huong Thi Tran Thuy Phan Junya Nakamura Tomoe Iwata Keisuke Harano Yushi Ishibashi Takashi Yuasa Mari Iwaya-Inoue; Heat stress induces expression of a set of thermotolerance-related genes in plants. We focused on rice (Oryza sativa L.) homologs of the gene family that encodes galactinol synthase (OsGolS), which is closely related ...; 关键词：GALACTINOL SYNTHASE GELDANAMYCIN HEAT Shock Factor HEAT Shock Protein Oryza SATIVA

In vivoeffects of genistein, herbimycin a and geldanamycin on rat hepatic cytochrome P4501A: 《Journal of Biophysical Chemistry》2012年第4期334-340,共7页Maria L. Perepechaeva Alevtina Y. Grishanova; Cytochrome P4501A (the CYP1A1 and CYP1A2 enzymes) are regulated through the aryl hydrocarbon receptor (AhR)-dependent signal transduction pathway and are generally known as enzymes which metabolize anthropogenic xenob...; 关键词：Protein-Tyrosine Kinase Aryl Hydrocarbon Receptor CYTOCHROMES P450 1A Regulation

Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment被引量：7: 《Acta Pharmaceutica Sinica B》2012年第3期238-245,共8页Yong Li Dongmei Zhang Jun Xu Junmin Shi Lei Jiang Nan Yao Wencai Ye; This work was supported by National Science Foundation of China(90913020 and 30901847);Science and Technology Program of China(2012ZX09103-101-053);Science and Technology Star of Zhujiang of Guangzhou City(Dongmei Zhang).; Heat shock protein 90(Hsp90)is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers.Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones ...; 关键词：Heat shock protein 90(Hsp90) TUMOR Hsp90 inhibitors GELDANAMYCIN

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