financial support from National Natural Science Foundation of China (21676113, 21402057, 21472059);Youth Chen-Guang Project of Wuhan (2016070204010098 );Supported by the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Shenzhen;Financially supported by self-determined research funds of CCNU from the college’basic research and operation of MOE (CCNU16A02004)~~