supported by the National Natural Science Foundation of China(No.31200828,31271155 and 81601158);the Key Projects of Outstanding Young Talent Support Program in Colleges and Universities of Anhui Province,China(No.gxyqZD2016175);the Natural Science Research Project Fund for Colleges and Universities in Anhui Province,China(No.KJ2018A0266);the Doctor Startup Fund in Wannan Medical College(No.rcqd201609)