Undefined familial colorectal cancer  

作　　者：Constantinos Pantelis Zambirinis George Theodoropoulos Maria Gazouli 

机构地区：[1]First Propaedeutic Surgical Department,Hippocration University Hospital,School of Medicine,University of Athens [2]Department of Biology,School of Medicine,University of Athens

出　　处：《World Journal of Gastrointestinal Oncology》2009年第1期12-20,共9页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Colorectal cancer(CRC),one of the most common cancers of the world,is actually a spectrum of several subtypes,with different molecular profiles,clinicopathological characteristics and possibly separate pathways of progression.It is estimated that in approximately 25-35 of cases,a familial component exists,so they are classified as familial CRC(fCRC).However the known hereditary CRC syndromes justify only up to 5.The rest are attributed to some inherited genetic predisposition passed to offspring through lowpenetrance genes,which in the proper environmental setting can bring on tumorigenesis.Furthermore,part of the familial clustering may be attributed to chance.Because of the complexity regarding the etiology of CRC,the clinician is sometimes faced with obscure patient data,and cannot be sure if they are dealing with fCRC or sporadic CRC.The elucidation of what is going on with the as yet "undefined" portion of CRC will aid not only in the diagnosis,classification and treatment of CRC,but more importantly in the proper adjustment of the screening guidelines and in genetic counselling of patients.Colorectal cancer (CRC), one of the most common cancers of the world, is actually a spectrum of several subtypes, with different molecular profiles, clinico-pathological characteristics and possibly separate pathways of progression. It is estimated that in approximately 25%-35% of cases, a familial component exists, so they are classified as familial CRC (fCRC). However the known hereditary CRC syndromes justify only up to 5%. The rest are attributed to some inherited genetic predisposition passed to offspring through low-penetrance genes, which in the proper environmental setting can bring on tumorigenesis. Furthermore, part of the familial clustering may be attributed to chance. Because of the complexity regarding the etiology of CRC, the clinician is sometimes faced with obscure patient data, and cannot be sure if they are dealing with fCRC or sporadic CRC. The elucidation of what is going on with the as yet“ undefined” portion of CRC will aid not only in the diagnosis, classification and treatment of CRC, but more importantly in the proper adjustment of the screening guidelines and in genetic counselling of patients.

关 键 词：COLORECTAL CANCER FAMILIAL Undefined TYPE X POLYMORPHISMS 

分 类 号：R735.3[医药卫生—肿瘤]