Toll-like receptors are potential therapeutic targets in rheumatoid arthritis  

作　　者：Siamak Sandoghchian Shotorbani 

机构地区：[1]Department of Immunology, Institute of Laboratory Medicine, Jiangsu University

出　　处：《World Journal of Biological Chemistry》2011年第7期167-172,共6页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by The National Natural Science Foundation of China (30871193, 30972748, 81001319);the Natural Science Foundation of Colleges and Universities in Jiangsu Province(Grant No. 09KJB310001);Innovation Fund for Candidate of Doctor in Jiangsu Province(Grant No.CX09B_217Z)

摘　　要：Toll-like receptors (TLRs) are found on the membranes of pattern recognition receptors and not only play important roles in activating immune responses but are also involved in the pathogenesis of inflammatory disease, injury and cancer. Furthermore, TLRs are also able to recognize endogenous alarmins released by damaged tissue and necrosis and/or apoptotic cells and are present in numerous autoimmune diseases. Therefore, the release of endogenous TLR ligands plays an important role in initiating and driving inflammatory diseases. Increasing data suggest a role for TLR signaling in rheumatoid arthritis, which is an autoimmune disease. Although their involvement is not comprehensively understood, the TLRs signaling transducers may provide potential therapeutic targets.Toll-like receptors (TLRs) are found on the membranes of pattern recognition receptors and not only play important roles in activating immune responses but are also involved in the pathogenesis of inflammatory disease, injury and cancer. Furthermore, TLRs are also able to recognize endogenous alarmins released by damaged tissue and necrosis and/or apoptotic cells and are present in numerous autoimmune diseases. Therefore, the release of endogenous TLR ligands plays an important role in initiating and driving inflammatory diseases. Increasing data suggest a role for TLR signaling in rheumatoid arthritis, which is an autoimmune disease. Although their involvement is not comprehensively understood, the TLRs signaling transducers may provide potential therapeutic targets.

关 键 词：AUTOIMMUNE disease INNATE immunity Pattern recognition RECEPTORS RHEUMATOID ARTHRITIS TOLL-LIKE RECEPTORS 

分 类 号：R593.22[医药卫生—内科学]