706例供精者染色体分析  

A Chromosome Analysis of 706 Donors

作　　者：朱文兵[1] 郑清[1] 谭跃球[1] 李麓芸[1] 范立青[1] 曾亚荣[1] 卢光琇[1] 

机构地区：[1]中南大学生殖与干细胞工程研究所中信湘雅生殖与遗传专科医院,湖南长沙410078

出　　处：《实用预防医学》2005年第1期18-19,共2页Practical Preventive Medicine

基　　金：国家自然科学基金 (30 1 70 4 80;30 4 70 884)

摘　　要：目的　研究染色体分析在精子库供精者 (Donor)筛查中的作用 ,防止供精人工受精后出生遗传病患儿。　方法　应用染色体G显带 ,对 70 6例Donor的染色体进行分析。　结果　 70 6例Donor染色体中 ,染色体异常 12例 [inv(9) ] ,共有多态 76例 (Yqh + 73例 ,16qh + 3例 )。　 结论　供精者个体存在染色体异常且以 9号染色体倒位为主 ,供精者个体存在较高频率的大Y ,其临床意义有待于积累更多资料。Objective To study the effect of chromosomal factors on sperm bank screening and prevent baby born with gentic abnormality from artificial insemination. Method Karyotypes of 706 donor were analyzed by chromosome G banding. Result Abnormal Karyotypes were found in 12 cases and the abnormal rate was 1.70%.Polymorphism was found in 76 cases and the polymorphism rate was 10.76%. Conclusion Chromosome 9 abnormality is an important factor in donors, and there is a high big Y chromosome rate in donors, whose clinical significance is to be studied with more accumulation of data.

关 键 词：染色体分析 染色体异常 INV(9) 大Y 倒位 精子库 染色体G显带 人工受精 积累 出生 

分 类 号：R596[医药卫生—内科学] R714[医药卫生—临床医学]