大豆异黄酮糖苷及其苷元调节免疫功能的比较研究  

Immunological Regulation Comparisons about Soybean Isoflavones and Free Aglycone

作　　者：李长彪[1] 赵秀红[1] 刘长江[1] 孟宪文[1] 高荣海[1] 张春红[1] 

机构地区：[1]沈阳农业大学食品学院,辽宁沈阳110161

出　　处：《食品科学》2007年第5期320-323,共4页Food Science

基　　金：辽宁省科技厅科技攻关课题(2004205001)

摘　　要：目的:比较大豆异黄酮糖苷及游离型大豆苷元对小鼠免疫功能能力的影响。方法:将实验室提取大豆异黄酮糖苷和苷元(纯度为41%左右)的产品按照40～100mg/kg,连续灌胃21d后,与对照组相比能显著提高小鼠腹腔巨噬细胞的吞噬能力及小鼠脾重。结果:大豆异黄酮糖苷和苷元具有较强的调节小鼠腹腔巨噬细胞的吞噬能力,能刺激小鼠脾脏和胸腺器官的发育;同一剂量的大豆异黄酮糖苷和苷元雌鼠的效果要好于雄鼠,游离型大豆苷元的吸收效果明显好于糖苷。Object： The purpose is to compare the effects of soybean isoflavones and flee aglycone for improving mouse humoral immunity. Methods： The mice were instilled with soybean isoflavone and aglycone respectively 40-100mg/kg for 21day continually.Immunological analysis showed the phagacytosis index and the weight of spleen. The results indicated that both the soybean isoflavones and the free agiycone can significantly improve the phagocytosing function of celiac macrophage, and stimulate the growth of spleen and thymus. The trigger effects in the female mice are much better than the male mice for the administration of either soybean isoflavones or free aglycone, whereas the absorbing effects of free aglycone are better than those of soybean isoflavones.

关 键 词：大豆异黄酮 大豆异黄酮苷元 免疫功能 

分 类 号：R151[医药卫生—营养与食品卫生学]