总N-亚硝基化合物接触量与胃癌死亡率的生态学相关性  

THE CORRELATION BETWEEN EXPOSURE TO TOTAL N-NITROSO COMPOUNDS AND MORTALITY OF STOMACH CANCER

作　　者：吴永宁[1] 王绪卿[1] 陈孝曙[1] 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所,北京100050

出　　处：《环境化学》1997年第2期125-129,共5页Environmental Chemistry

基　　金：国家自然科学基金青年基金;国家人事部非教育系统回国留学人员基金;卫生部回国留学人员启动基金资助项目

摘　　要：在胃癌高发区福建省长乐县和低发区山东省崂山县各随机选择近60名35—64岁男性,采用双份饭法收集24h膳食和12h尿液,测定总N-亚硝基化合物(TNOC)含量,计算膳食摄入量和尿中排出量.人群日均膳食援入量高发区为7.07±4.31μmol,低发区为4.07±3.67μmol,P<0.001;12h尿中排出量高发区为1.13±0.61μmol,低发区为0.34±0.27μmol,P<0.001;尿中排出量与膳食摄入量之间存在显著相关对(r=0.65,P<0.01),据此可以12h尿中排出量来推测日均摄入量.随之在覆盖我国胃癌死亡率的13个县各采集60份尿样进行生态学相关研究,发现胃癌死亡率与TNOC尿中排出量呈正相关(r=0.72,P<0.05).Duplicate portion diet samples and 12h overnight urine samples were collected from approximately 60 males adults in 2 areas of different risk of gastric cancer, the Changle of Fujian province,a high-risk area and Laoshan of Shangdong province,a low-risk area. Daily dietary intakes and urinary excretion of total N-nitroso compound (TNOC) were investigated. The dietary intake was significantly higher in high-risk area ( 7. 07+_ 4. 31μmol·d-1) than low-risk area (4. 07 ± 3. 67μmol·d-1) , urinary excretion was also higher in high-risk area(1.13 ± 0.61μmol·12h-1) than low-risk area(0. 34 ± 0. 27μmol·12h-1). There was good correlation between urinary excretion and dietary intake of TNOC (r=0.65, P<0.05), which indicated TNOC excretion in 12h overnight urine could be index of daily dietary nitrate intake. The correlation study in 13 counties showed that there was a moderate tendency for gastric cancer mortality to be associated positively with urinary TNOC excretion (r = 0. 72, P<0. 05).

关 键 词：膳食摄入 尿液排泄 胃肿瘤 生态学 亚硝基化合物 

分 类 号：R735.202[医药卫生—肿瘤] R994.6[医药卫生—临床医学]