180例生殖异常患者染色体核型分析  

180 samples analysis of chromosome from reproduction abnormality patients

作　　者：杨晓[1] 王春枝[1] 朱丽娜[1] 何玺玉[1] 马宁[1] 王蔚[1] 刘欣[1] 封志纯[1] 

机构地区：[1]北京军区总医院附属八一儿童医院临床遗传学中心,北京100700

出　　处：《中国优生与遗传杂志》2009年第4期51-52,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨生殖异常与染色体异常的关系。方法检测180例生殖异常患者外周血淋巴细胞染色体核型。结果180例有不孕不育、畸形、死胎、习惯性流产患者染色体检查出异常核型13例,其中4例克氏综合征(K linefelter综合征),3例平衡易位,3例罗伯逊易位,2例臂间倒位,1例大Y染色体。结论染色体异常是导致不孕不育及自发流产的重要原因之一,对生殖异常患者进行染色体检查可为临床诊断和优生优育提供依据。Objective： To investigate the relationship between reproductive abnormalities and chromosome abnormalities . Methods： 180 reproduction abnormality patients＇were performed by peripheral blood lymphocytes cultivating to make chromosome G- banding. results： 13 of 180 cases of patients （7.2%） were abnormal chromosome karyotypes. Among 4 case are Klinefeher＇syndromes, 3 case are chromosome balanced translocations, 3 case are chromosome Robertson translocations, 2 cases are inversion chromosome, 1 case are polymorphism of Y - chromosome. Conclusion ： Chromosome abnormalities are the important factors resulting in female/male infertilities, we advocate that should try to do chromosome investigation for reproduction abnormality oatients.

关 键 词：染色体 染色体异常核型 生殖异常 

分 类 号：R394[医药卫生—医学遗传学]