河豚毒素及其发酵生产的研究进展  

Research Advances in Tetrodotoxin and Its Fermentation

作　　者：谷江稳[1] 徐善良[2] 颜付云[1] 陈宣雄[1] 

机构地区：[1]宁波大学海洋生物工程浙江省重点实验室,浙江宁波315211 [2]宁波大学应用海洋生物技术教育部重点实验室,浙江宁波315211

出　　处：《食品科学》2010年第11期298-302,共5页Food Science

摘　　要：河豚毒素(tetrodotoxin,TTX)常见于河豚体内,是一种毒性很强的氨基全氢化喹唑啉化合物。它是世界上最致命的生物毒素之一,同时也是对神经有选择性作用的强效麻醉药和戒毒良药。因此,科研人员在弄清TTX的产生途径及产生菌后,正在竭力研究其生产工艺及高产方式,以使其显著的医药学价值为人类所用。本文综述TTX的起源、理化性质及其生物活性等基本特性,并重点介绍近年的研究方向和热点问题,即TTX的产生菌和发酵生产等方面的研究。Tetrodotoxin（TTX） is a highly toxic amino hydrogenated quinazoline compound in puffer fish.TTX is one of the most lethal biological toxins.It is also a powerful anesthetic and detoxification agent.Therefore,further studies on preparation technology and high-yield strategies of TTX for extending its medicinal values are being conducted according to the understanding of its generation pathways and TTX-producing strains.In this paper,basic characteristics of TTX including the origin,physical and chemical properties,biological activity are reviewed.In addition,current hot research direction and corresponding issues such as TTX-producing strain and its fermentation are also comprehensively analyzed.

关 键 词：河豚 河豚毒素 TTX 产生菌 发酵 

分 类 号：R996.3[医药卫生—毒理学]