富硒沼泽红假单胞菌G3菌与牛初乳复配改善小鼠免疫功能的作用研究  

Combined Effect of Bovine Colostrumson and Selenium-enriched Rhodopseudomonas palustris G3 on Immune Function in Mice

作　　者：杨启银[1,2,3] 王家芳[1] 贾秉晟[1] 管海华[1] 刘青[1] 

机构地区：[1]南京师范大学生命科学学院,江苏南京210046 [2]南京市微生物工程技术研究中心,江苏南京210046 [3]江苏省微生物资源工程化技术研究中心,江苏南京210046

出　　处：《食品科学》2010年第21期373-377,共5页Food Science

基　　金：江苏省科学技术厅高新技术项目(BG2005326)

摘　　要：目的:探讨富硒沼泽红假单胞菌G3菌(简称富硒G3菌)与牛初乳复配对小鼠免疫功能的影响。方法:将富G3菌与牛初乳复配形成富硒牛初乳,用环磷酰胺构建小鼠免疫低下模型,对免疫低下小鼠灌胃富硒G3菌、牛初乳和富硒牛初乳,50d后测定各组小鼠脏器指数、白细胞数、T淋巴细胞阳性率、血清SOD酶活性、全血GSH-Px活性,同时计算平均每日进食饲料质量与体质量增加量的比值。结果:富硒G3菌、牛初乳、富硒牛初乳均能提高免疫低下小鼠对饲料的利用率,能提高免疫低下小鼠SOD、GSH-Px活性、白细胞数和T淋巴细胞阳性率,其中富硒牛初乳高剂量组效果最为明显,说明富硒牛初乳高剂量组能显著增强小鼠的免疫功能。In order to investigate the effect of selenium-enriched bovine colostrumson on immune function of immunodepressed mice induced by cyclophosphamide,selenium-enriched Rhodopseudomonas palustris G3 （hereinafter called selenium-enriched G3） was mixed with bovine colostrumson to prepare selenium-enriched bovine colostrumson.The immunodepressed mice were treated with selenium-enriched G3,bovine colostrumson and selenium-enriched bovine colostrumson,respectively.The administration was carried out once a day for 47 successive days after 3 days of adaptive feeding,and organ index,white blood cell number,T-cell population,the contents of SOD and GSH-Px in blood,and feed/gain ratio of mice were determined at the end of the administration.Results indicated that selenium-enriched G3,bovine colostrumson and selenium-enriched bovine colostrumson could increase the utilization efficiency of diet,enhance the activities of SOD and GSH-Px in blood,and improve mouse immune function.Compared with the control group,the selenium-enriched bovine colostrumson exhibited best improved immune at the high dosage.

关 键 词：硒 牛初乳 沼泽红假单胞菌 环磷酰胺 免疫功能 

分 类 号：TQ929.3[轻工技术与工程—发酵工程]