植物乳杆菌C88对小鼠急性毒性和细菌易位实验研究  

Acute Oral Toxicity and Bacterial Translocation Evaluation of Lactobacillus Plantarum C88

作　　者：黄丽[1,2] 李盛钰[1] 赵玉娟[1] 张雪[1] 曾先鹏[1] 杨贞耐[1] 

机构地区：[1]吉林省农业科学院农产品加工研究中心国家乳品加工技术研发分中心,长春130033 [2]东北师范大学生命科学学院,长春130024

出　　处：《中国食品学报》2012年第6期9-15,共7页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(No31071574);农业部现代农业产业技术体系建设专项资金资助项目(nycytx-0502);吉林省博士后基金项目(200904008)共同资助

摘　　要：通过小鼠急性毒性和细菌移位实验,评价1株具有潜在益生特性的植物乳杆菌(Lactobacillus plantarum)C88的安全性,为该菌株的安全应用提供依据。对小鼠连续14d灌胃不同剂量的植物乳杆菌C88,结果表明C88各剂量组小鼠一般体征、脏器指数、血清和肝脏生化指标与对照组相比差异不显著(P>0.05)。植物乳杆菌C88各剂量组小鼠血液和其它组织样本中均未检测到活的植物乳杆菌C88细胞,说明无细菌移位发生,植物乳杆菌C88安全,无毒副作用。The acute oral toxicity and bacterial translocation of Lactobacillus plantarum C88, a potential new probiotic, were studied in mice to provide evidence for safety application. Different dose of L. plantarum C88 were given to mice orally by gavage for 14 consecutive days. Compared with control, there were on significant differences （P〉0.05） in general signs, organs index, or biochemistry parameters of serum and liver with different dose of L. plantarum C88. No treatment-associated bacterial translocation was detected in any group. The result of acute toxicity and bacterial translocation showed that L. plantarum C88 had no toxicity and side effects.

关 键 词：植物乳杆菌 安全性评价 急性毒性 细菌移位 

分 类 号：TS201.3[轻工技术与工程—食品科学]