Angiogenesis and liver fibrosis  

作　　者：Gulsum Ozlem Elpek 

机构地区：[1]Department of Pathology Akdeniz University Medical School

出　　处：《World Journal of Hepatology》2015年第3期377-391,共15页世界肝病学杂志（英文版）（电子版）

摘　　要：Recent data indicate that hepatic angiogenesis, regardless of the etiology, takes place in chronic liver diseases(CLDs) that are characterized by inflammat ion and progre s s ive f ibros is. B e c aus e ant iangiogenic therapy has been found to be efficient in the prevention of fibrosis in experimental models of CLDs, it is suggested that blocking angiogenesis could be a promising therapeutic option in patients with advanced fibrosis. Consequently, efforts are being directed to revealing the mechanisms involved in angiogenesis during the progression of liver fibrosis. Literature evidences indicate that hepatic angiogenesis and fibrosis are closely related in both clinical andexperimental conditions. Hypoxia is a major inducer of angiogenesis together with inflammation and hepatic stellate cells. These profibrogenic cells stand at the intersection between inflammation, angiogenesis and fibrosis and play also a pivotal role in angiogenesis. This review mainly focuses to give a clear view on the relevant features that communicate angiogenesis with progression of fibrosis in CLDs towards the-end point of cirrhosis that may be translated into future therapies. The pathogenesis of hepatic angiogenesis associated with portal hypertension, viral hepatitis, non-alcoholic fatty liver disease and alcoholic liver disease are also discussed to emphasize the various mechanisms involved in angiogenesis during liver fibrogenesis.Recent data indicate that hepatic angiogenesis, regardless of the etiology, takes place in chronic liver diseases(CLDs) that are characterized by inflammat ion and progre s s ive f ibros is. B e c aus e ant iangiogenic therapy has been found to be efficient in the prevention of fibrosis in experimental models of CLDs, it is suggested that blocking angiogenesis could be a promising therapeutic option in patients with advanced fibrosis. Consequently, efforts are being directed to revealing the mechanisms involved in angiogenesis during the progression of liver fibrosis. Literature evidences indicate that hepatic angiogenesis and fibrosis are closely related in both clinical andexperimental conditions. Hypoxia is a major inducer of angiogenesis together with inflammation and hepatic stellate cells. These profibrogenic cells stand at the intersection between inflammation, angiogenesis and fibrosis and play also a pivotal role in angiogenesis. This review mainly focuses to give a clear view on the relevant features that communicate angiogenesis with progression of fibrosis in CLDs towards the-end point of cirrhosis that may be translated into future therapies. The pathogenesis of hepatic angiogenesis associated with portal hypertension, viral hepatitis, non-alcoholic fatty liver disease and alcoholic liver disease are also discussed to emphasize the various mechanisms involved in angiogenesis during liver fibrogenesis.

关 键 词：Liver fibrosis ANGIOGENESIS CIRRHOSIS FIBROGENESIS Hepatic stellate cells Vascular endothelial growth factor HYPOXIA Chronic liver disease 

分 类 号：R[医药卫生]