FIBROGENESIS

作品数：46被引量：605H指数：15
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相关作者：陈志南边惠洁李浩吴佼更多>>
相关机构：第四军医大学同济大学上海中医药大学更多>>
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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway
《Current Medical Science》2024年第3期519-528,共10页Jia SONG Dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG 
supported by grants from the National Natural Science Foundation of China(No.82270545 and No.81870381);Natural Science Foundation of Hebei Province(No.H2014206446)。
Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium ...
关键词：tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease MYOFIBROBLASTS transforming growth factor-β1 
Gut microbiota controls the development of chronic pancreatitis:A critical role of short-chain fatty acids-producing Gram-positive bacteria被引量：7
《Acta Pharmaceutica Sinica B》2023年第10期4202-4216,共15页Li-Long Pan Zheng-Nan Ren Jun Yang Bin-Bin Li Yi-Wen Huang Dong-Xiao Song Xuan Li Jia-Jia Xu Madhav Bhatia Duo-Wu Zou Chun-Hua Zhou Jia Sun 
supported by funds from the National Natural Science Foundation of China(Grant Nos.82070666,82122068);the Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province(Grant No.BK20200026,China);the Collaborative Innovation Center of Food Safety and Quality Control of Jiangsu Province,the Fundamental Research Funds for the Central Universities(Grant Nos.JUSRP221037,JUSRP22007,China);the China Postdoctoral Science Foundation(Grant No.2022M721366);the Excellent Postdoctoral Program of Jiangsu Province(Grant No.2023ZB168,China);Wuxi City’s first“double hundred”young and middle-aged medical and health talents(Grant No:BJ2020045,China);Wuxi Social Development Science and Technology Demonstration Project(Grant No:N20201003,China)。
Chronic pancreatitis(CP)is a progressive and irreversible fibroinflammatory disorder,accompanied by pancreatic exocrine insufficiency and dysregulated gut microbiota.Recently,accumulating evidence has supported a corr...
关键词：Chronic pancreatitis Antibiotic exposure Gut microbiota Short-chain fatty acids-producing bacteria Pancreatic fibrogenesis Macrophage responses Toll-like receptor 4 
Potential biomarkers for diagnosis and disease evaluation of idiopathic pulmonary fibrosis被引量：2
《Chinese Medical Journal》2023年第11期1278-1290,共13页Qing Wang Zhaoliang Xie Nansheng Wan Lei Yang Zhixian Jin Fang Jin Zhaoming Huang Min Chen Huiming Wang Jing Feng 
National Natural Science Foundation of China(Nos.81970083 and 82170097)
Idiopathic pulmonary fibrosis(IPF)is a chronic progressive lung disease characterized by progressive lung fibrogenesis and histological features of usual interstitial pneumonia.IPF has a poor prognosis and presents a ...
关键词：Alveolar epithelial cell dysfunction BIOMARKER DIAGNOSIS FIBROGENESIS Extracellular matrix remodeling Idiopathic pulmonary fibrosis Immune dysfunction 
Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma被引量：5
《World Journal of Gastroenterology》2022年第36期5250-5264,共15页Aswathy R Devan Keechilat Pavithran Bhagyalakshmi Nair Maneesha Murali Lekshmi R Nath 
Supported by the Amrita Vishwa Vidyapeetham SEED grant (K-PHAR-22-662)
Transforming growth factor-beta(TGF-β)is a multifunctional cytokine that performs a dual role as a tumor suppressor and tumor promoter during cancer progression.Among different ligands of the TGF-βfamily,TGF-β1 mod...
关键词：Transforming growth factor-beta 1 Inflammation IMMUNOSUPPRESSION FIBROGENESIS Hepatocellular carcinoma Biomarker IMMUNOTHERAPY 
Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients被引量：4
《World Journal of Hepatology》2021年第2期218-232,共15页Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes 
the National Council for Science and Technology,No.SALUD-2016-272579 and No.PAPIIT-UNAM TA200515.
BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few s...
关键词：Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C FIBROGENESIS Fibrolysis 
Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells被引量：23
《Acta Biochimica et Biophysica Sinica》2020年第8期810-820,共11页Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang 
This work was supported by the grants from the National Natural Science Foundation of China(No.81270092);the Free Exploration Fundation of Hubei University of Medicine(No.FDFR201801).
Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti...
关键词：ISOLIQUIRITIGENIN TGF-Β1 AUTOPHAGY pulmonary fibrosis PI3K/AKT mTOR 
Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells被引量：6
《World Journal of Gastroenterology》2019年第9期1067-1079,共13页Xing-Qiu Liang Jian Liang Xiao-Fang Zhao Xin-Yuan Wang Xin Deng 
the National Natural Science Foundation of China,No.81360595 and No.81860790;Guangxi Natural Science Foundation Program,No.KJT13066;the Bagui Scholars Foundation Program of Guangxi;the Special-term Experts Foundation Program of Guangxi;the Project of Guangxi Young Teacher Fundamental Ability Promotion,No.2017KY0298
BACKGROUND Studies show that the antifibrotic mechanism of taurine may involve its inhibition of the activation and proliferation of hepatic stellate cells(HSCs). Since the molecular mechanism of taurine-mediated anti...
关键词：TAURINE Hepatic stellate cells DIFFERENTIALLY EXPRESSED genes Liver FIBROGENESIS TRANSCRIPTOMIC PROTEIN-PROTEIN interaction network 
Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis被引量：1
《Journal of Bio-X Research》2019年第1期16-24,共9页Zhipeng Liu Naga Chalasani Jingmei Lin Samer Gawrieh Yuan He Yan J.Tseng Wanqing Liu 
supported in part by a NIH grant,No.R01 DK106540(to WL).
The genetic basis underlying liver fibrosis remains largely unknown.We conducted a study to identify genetic alleles and underlying pathways associated with hepatic fibrogenesis and fibrosis at the genome-wide level i...
关键词：hepatic fibrosis GENOMICS macrophage migration inhibitory factor alpha-smooth muscle actin pathway enrichment analysis genetic susceptibility 
Iron metabolism disorders in patients with hepatitis B-related liver diseases被引量：12
《World Journal of Clinical Cases》2018年第13期600-610,共11页Yan-Hang Gao Jing-Yun Wang Pei-Yan Liu Jing Sun Xiao-Mei Wang Rui-Hong Wu Xiu-Ting He Zheng-Kun Tu Chun-Guang Wang Hong-Qin Xu Jun-Qi Niu 
Supported by the National Science and Technology Major Project,No.2014ZX10002002 and No.2017ZX10202202;the National Key Research Plan "Precision Medicine Research" Key Project,No.2017YFC0908103;the National Natural Science Foundation of China,No.81700534;Program for JLU Science and Technology Innovative Research Team,No.2017TD-08
AIM To investigate the relationship between levels of iron metabolism markers and hepatitis B virus(HBV)-related chronic liver diseases.METHODS This case-control study with 318 participants included 78 cases of chroni...
关键词：HEPATOCELLULAR CARCINOMA HEPCIDIN Iron STAINING HEPATITIS B Liver FIBROGENESIS 
Fibrogenesis in inflammatory bowel disease——A bright road ahead
《中华炎性肠病杂志（中英文）》2018年第1期3-4,共2页Florian Rieder Claudio Fiocchi 
Intestinal fibrosis is a frequent complication of inflammatory bowel diseases (IBD),and can lead to stricture formation and intestinal obstruction. Clinically apparent stenosis occurs in more than 30% of patients with...
关键词：FIBROGENESIS AHEAD STENOSIS 
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