青刺尖茶对高血脂症小鼠降脂的效果  

Effect of Prinsepia utilis tea on blood lipids in hyperlipidemic mice

作　　者：杨妍[1] 刘刚[1] 张晓喻[1] 胡婷婷[1] 王战国[2] 黎霞[1] 李慧敏[1] 

机构地区：[1]四川师范大学生命科学学院,四川成都610101 [2]四川大学生命科学院,四川成都610041

出　　处：《食品工业科技》2015年第13期361-363,367,共4页Science and Technology of Food Industry

基　　金：四川师范大学大精设备开放基金项目(DJ2014-07);四川师范大学项目(14yb29);四川师范大学"土壤污染原位修复与绿色食品药品开发"创新团队项目;攀枝花市科技局项目(2014CY-C-1);西昌市教育和科学计划局2014年度科技项目

摘　　要：目的:探讨青刺尖茶汤对高血脂症模型小鼠的降血脂作用。方法:高脂饲料喂养小鼠28d,建立高血脂症模型小鼠后随机分成5组,即模型组、青刺尖茶汤低、中和高3个剂量处理组(2、6和9g/kg·bw)及血脂康阳性组(3g/kg·bw),以普通饲料喂养的同批小鼠作空白组。实验期间各组小鼠取食正常,毛洁白具光泽,且无排稀便现象。进行连续灌胃给药28d,心脏取血分离血清,检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的含量,同时,计算肝脏指数及小鼠体重的增长量。结果:与模型组比较,各处理组的血清TG、LDL-C均显著降低(p<0.05),血清TC、HDL-C和肝脏指数均极显著降低(p<0.01);高剂量组的血清LDL-C与模型组的差异也达到极显著(p<0.01)。与空白组比较,各处理组体重的增长量均降低,低、中剂量组达极显著(p<0.01),高剂量组为显著(p<0.05),同时,模型组的肝脏指数显著升高(p<0.05),但各处理组的肝脏指数无显著差异。与模型组比较,各处理组体重的增长量、肝脏指数的降低,均呈现极显著(p<0.01)。与阳性组比较,各处理组体重的增长量、肝脏指数,均无差异性。结论:青刺尖茶汤具有控制高血脂症小鼠体重的增加、降低肝脏指数的作用,并显示良好的降低血清4项血脂指标的功效,因此,青刺尖茶具有降低高血脂症小鼠血脂的效果,显示其降血脂功能。Objective：To study the effect of Prinsepia utilis tea on blood lipid in mouse model of hyperlipidemia. Method：The hyperlipidemia mouse model was induced by high fat diet successfully and the mice were randomly divided into blank group, model group, Iow（2g/kg. bw）, middle （6g/kg· bw）, high （9g/kg·bw） dose group of Prinsepia utilis tea and positive in group.After treatment of 28d by gastric gavage, serum total cholesefol （TC）, riglyceride（ TG）, high density lipoprotein cholesterol （ HDL- C） and low density lipoprotein cholesterol （ LDL- C） levels were measured by automatic biochemical analyzer,liver index was calculated.Result：Serum TG and LDL-C in Prinsepia utilis tea groups were notably lower than model group （p 〈 0.05 ） ;serum TC, HDL-C, weight increase and liver index were significantly lower than model group （p 〈 0.01 ）, LDL-C in high dose group was significantly lower than model group（p 〈0.01 ）.Weight increase in Prinsepia utilis tea groups were lower than blank group, low and middle dose group was significantly lower than blank group （ p 〈 0.01 ）, high dose group were notably lower than blank group（ p 〈 0.05）, liver index in model group was notably higher than blank group （p 〈 0.05 ）.Compared each Prinsepia utilis tea group with model group,TC,TG, LDL-C, HDL-C,weight increase and liver index were not significantly different.Conclusion ： Prinsepia utilis tea has weight relief and evident hypolipemia effect.

关 键 词：青刺尖茶汤 高血脂 降血脂 

分 类 号：TS272.5[农业科学—茶叶生产加工]