微生物发酵法制备维生素K2研究进展  

Research progress on vitamin K2 by microorganism fermentation

作　　者：罗苗苗[1] 胡学超[1] 邱宏伟 刘维明[1] 任路静[1] 黄和[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211800 [2]丽水双健生物工程有限公司,浙江丽水323000

出　　处：《食品与发酵工业》2015年第10期221-225,共5页Food and Fermentation Industries

基　　金：国家863计划(No.2014AA021701);国家自然科学基金(21306085);高等学校博士学科点专项科研基金(20133221120008)

摘　　要：维生素K2是一类必不可少的人体内源性高活性维生素,为甲萘醌类系列化合物,纳豆芽孢杆菌(Bacillus subtilis natto)因能高产维生素K2而成为当前国内外研究热点。文中对纳豆芽孢杆菌及其合成维生素K2的机理进行了简要介绍,对国内外微生物发酵产维生素K2的研究水平进行综述,并指出维生素K2是参与呼吸链的关键电子传递载体,在发酵过程中会形成水溶性复合物分泌至胞外。基于目前发酵状况,提出了维生素K2发酵过程中存在的问题,并指出今后发展方向,为实现维生素K2的高效合成和积累提供指导。Vitamin K2 is an essential endogenous vitamin with high activity in human, and it belongs to the class of menaquinone. Bacillus subtilis natto has captured an international research hotspot because of its high yield of vita- min K2. In this article, Bacillus subtilis natto, its metabolic mechanism for vitamin K2 biosynthesis, the research lev- el of vitamin K2 are introduced. It points out that vitamin K2 is the key electronic delivery vector in the respiratory e- lectron chain system, which will form a water-soluble compounds for extracellular secretion in the fermentation process. In view of the present research situation, the problems existing in vitamin K2 fermentation process are also mentioned. The future research direction is also pointed out, which would give guidance to realize the efficient synthe- sis and accumulation of vitamin K2.

关 键 词：纳豆芽孢杆菌 维生素K2 发酵 代谢途径 

分 类 号：TQ924[轻工技术与工程—发酵工程]