蕈类β葡聚糖的提纯、结构及抗肿瘤研究进展  

Extraction,Purification,Structure,and Anti-tumor Activity ofβglucan from Edible Fungi——A Review

作　　者：郑恒光[1] 陈君琛[1] 汤葆莎[1] 吴俐[1] 翁敏劼[1] 高慧颖[1] 

机构地区：[1]福建省农业科学院农业工程技术研究所,福建福州350003

出　　处：《福建农业学报》2016年第2期205-209,共5页Fujian Journal of Agricultural Sciences

基　　金：福建省科技计划项目--省属公益类科研院所基本科研专项(2014R1015-11;2014R1015-1);福州市科技项目(2014-G-63)

摘　　要：蕈类β葡聚糖通常具有抗肿瘤功效,可从食用菌生产副产物(菇柄或残次菇)中大量提取,具有广阔的应用前景。本文简要概括了蕈类β葡聚糖的提取、纯化、化学结构、抗肿瘤活性等方面最新研究进展,指出了该研究领域的重点、难点,并提出后期研究方向:(1)开发专用多糖水解酶,在保留其生物活性的前提下,提高蕈类β葡聚糖的溶解度和提取率;(2)强化对蕈类β葡聚糖分子内部活性中心的研究;(3)广泛收集与蕈类β葡聚糖抗肿瘤活性相关的人体试验数据;(4)采用更高解析度的原子力显微镜直接观测蕈类β葡聚糖的构象等。β glucan in edible fungi is generally considered an anti-tumor substance.It can be extracted from discarded mushroom stipes or defected mushrooms for by-product utilization.However,at present,a lack of relevant information hinders its industrial development.This article summarizes the latest progress on the extraction, purification, chemical structure,and anti-tumour activity of β glucan,as well as the key issues,difficulties and deficiencies relating to the subject.Comments and suggestions for future research are presented that included：（1）development of specific hydrolase that could increase the solubility and extraction rate of the polysaccharide without sacrificing its anti-tumour activity,（2）study on the molecular activity center of the polysaccharide,（3）collection of clinic data on the anti-tumour effect of β glucan,and（4）application of atomic force microscopy with high solution to directly observe the chemical structure of β glucan.

关 键 词：食用菌 Β-葡聚糖 提取 纯化 结构 抗肿瘤 研究进展 

分 类 号：TS201.4[轻工技术与工程—食品科学]