木耳虫草胶囊对高脂血症大鼠的降血脂作用  

Efficacy of Muerchongcao on Reducing Serun Lipidin Hyperlipidemic Rats

作　　者：吴俐[1] 沈恒胜[1] 陈君琛[1] 翁敏劼[1] 李怡彬[1] 

机构地区：[1]福建省农业科学院农业工程技术研究所,福建福州350003

出　　处：《福建农业学报》2016年第6期657-662,共6页Fujian Journal of Agricultural Sciences

基　　金：农业部公益性行业(农业)科研(专项)(201303080);福建省科技计划项目--省属公益类科研院所基本科研专项(2014R1015-9)

摘　　要：采用高脂饮食法复制高血脂动物模型。研究木耳虫草胶囊对饮食性高脂血症大鼠的降血脂功能。动物试验设置空白对照组、高脂模型对照组、木耳虫草胶囊-低、中、高剂量处理组;木耳虫草胶囊-低、中、高3个剂量组分别灌胃27.0、54.0、81.0mg·kg^(-1)·d^(-1)木耳虫草胶囊28d,空白对照组和高脂模型对照组灌胃等体积生理盐水;观察木耳虫草胶囊对高脂血症大鼠血清、肝脏脂质代谢和小肠吸收代谢的影响。与高脂模型对照组比较,木耳虫草胶囊低剂量组低密度脂蛋白胆固醇(LDL-C)降低,中剂量组总胆固醇(TC)降低,高剂量组TC、LDL-C、甘油三酯(TG)均显著降低(P<0.01),同时各处理组血清高密度脂蛋白胆固醇(HDL-C)与模型对照组的HDL-C没有差异;中、高剂量组能极显著降低动脉粥样硬化指数(AI);各处理组的肝脏指数、肝小叶结构和脂肪变性的严重程度较模型对照组改善;各处理组的小肠绒毛高度和隐窝深度的比值较模型组明显减小。木耳虫草胶囊具有辅助降低血脂、胆固醇、甘油三酯功能和降低动脉粥样硬化指数的作用,并可部分改善高脂饮食对肝脏的损害,降低绒毛高度和隐窝深度的比值,从而减少饲料中脂肪的吸收。Efficacy of Muerchongcao capsules（MC）that contained the medicinal ingredients from Auricularia auricular（L.ex Hook）Underwood and Cordyceps militaris militaris（Fr.）Linkon the serum lipid reduction in Sprague-Dawley rats with hyperlipidemia induced by a high fat diet was studied.A4-week high fat diet followed by another 4weeks of MC treatments was the feeding program applied on the lab rats.Three levels of dosage,i.e.,27,54,and 81mg·kg^（-1）·d^（-1） of MC as low-,medium-,and high-dosegroups,respectively,were administeredby gavage to the rats.A control group without MC treatment along with a blank group fed with the basal diet and physiological saline was used simultaneously during the experiment.The serum lipid,heptic metabolism,and intestinal absorption and metabolism of the hyperlipidemic rats were monitored.The serum low-density lipoprotein cholesterol（LDL-C）of the rats in the low-dose MC treatment group,the serum total cholesterol（TC）in the medium-dose group,the serum TC,LDL-C,and total triglycerides（TG）in the high-dose group were found significantly lower than those in control group（P〈0.01）.The high-density lipoprotein cholesterol（HDL-C）in the treatment groups did not significantly differ from that in control group（P〉0.05）.The atherogenic index（AI）of the rats in the medium-dose and high-dose groups decreased significantly as compared to control.The liver index,hepatic lobule structure,and fatty degeneration in therats of MC treatment groups were better than those in control group,whereas,the villus：cryptratio（VCR）was significantly reduced.It appearedthat MC demonstrated a hypolipidemic and anti-atherogenic effect on the hyperlipidemic rats,as well as an ability to partially repair the liver damage induced by the high fat diet and reduce VCR inhibiting the absorption of dietary and biliary cholesterol in the small intestine of the rats.

关 键 词：木耳 蛹虫草 高血脂动物模型 降血脂 脂肪肝 

分 类 号：S646.9[农业科学—蔬菜学]