植物多酚通过PI3K/Akt信号通路抗肿瘤作用研究进展  

Plant Polyphenols Exert Anti-Tumor Activity by the PI3K/Akt Signaling Pathway: A Review

作　　者：石芳[1] 廖霞[1] 李瑶[1] 李谣[1] 肖星凝 吴素蕊[2] 明建[1,2,3] 

机构地区：[1]西南大学食品科学学院,重庆400715 [2]中华全国供销合作总社昆明食用菌研究所,云南昆明650223 [3]重庆市特色食品工程技术研究中心,重庆400715

出　　处：《食品科学》2016年第15期259-264,共6页Food Science

基　　金：国家自然科学基金面上项目(31471576);重庆市社会民生科技创新专项(cstc2015shmszx80019);"十二五"国家科技支撑计划项目(2013BAD16B01)

摘　　要：磷脂酰肌醇3-激酶/丝氨酸/苏氨酸激酶B(phosphatidylinositol 3-kinase/serine/threonine kinase B,PI3K/Akt)信号通路是一条经典的抑制细胞凋亡、促进细胞增殖的信号转导通路,在肿瘤、心血管疾病、神经系统疾病和糖尿病等的防治中发挥重要作用,特别是肿瘤。PI3K/Akt信号通路的异常活化与肿瘤的发生、侵袭和转移等过程密切相关,对该通路的研究已成为当今国内外治疗肿瘤的焦点。植物多酚因具有抗肿瘤作用而成为预防肿瘤的天然药物。本文综述了PI3K/Akt信号通路的结构、活化机制以及与肿瘤的关系,总结植物多酚通过该信号通路对肿瘤细胞的作用机制,以期为研发植物多酚作为预防肿瘤的保健食品或药品提供一定的科学依据。The phosphatidylinositol 3-kinase/serine/threonine kinase B （PI3K/Akt） signaling pathway is a classical signalingpathway that inhibits apoptosis and promotes proliferation. The PI3K/Akt pathway play an important role in cancer,cardiovascular disease, diabetes and nervous system diseases, especially in cancer. The abnormal activation of PI3K/Akt isclosely related to the occurrence, invasion and metastasis of tumors. The research of this pathway has become the focus ofthe treatment of cancer at home and abroad. Plant polyphenols are becoming natural drugs to prevent cancer because of theiranti-tumor effect. This review outlines the structure and activation mechanism of the PI3K/Akt signaling pathway and itsrelationship with tumor in order to provide scientific evidence for the development of plant polyphenols into health foods ordrugs for cancer prevention.

关 键 词：磷脂酰肌醇3-激酶/丝氨酸/苏氨酸激酶B 信号通路 植物多酚 抗肿瘤 

分 类 号：Q964.8[生物学—昆虫学] R151.2[医药卫生—营养与食品卫生学]