真菌毒素暴露对组蛋白修饰影响的研究进展  

Effect of mycotoxins exposure on histone modification homeostasis

作　　者：李晓红[1] 罗红霞[1] 句荣辉[1] 刘小飞[1] 田文静 谌小立[2] 施鹏飞 LI Xiao-hong;LUO Hong-xia;JU Rong-hui;LIU Xiao-fei;TIAN Wen-jing;SHEN Xiao-li;SHI Peng-fei(Beijing Agricultural Vocational College,Beijing 102442,China;School of Public Health,Zunyi Medical University,Zunyi 563000,China;Beijing Changping District Seed Management Station,Beijing 102200,China)

机构地区：[1]北京农业职业学院,北京102442 [2]遵义医学院公共卫生学院,贵州遵义563000 [3]北京市昌平区种子管理站,北京102200

出　　处：《食品与发酵工业》2018年第5期270-276,共7页Food and Fermentation Industries

基　　金：国家自然科学基金(31460426);北京农业职业学院院级项目(XY-YT-16-44);北京市农委项目(20160202-14);贵州省科学技术基金项目(黔科合LH字[2014]7546号);遵义医学院优秀青年人才项目(17zy-006);遵义医学院博士学位授权支撑学科建设经费(2015-996036)

摘　　要：天然存在的霉菌毒素的暴露会影响人体健康。环境中的许多真菌毒素会对组蛋白修饰状态产生影响,这种表观遗传改变在疾病的发生与发展中往往发挥重要作用。近年来,真菌毒素在表观遗传学层面的致毒机制也已成为研究热点。然而截止目前,专注于真菌毒素致毒的组蛋白修饰方面的综述仍然缺乏。文章综述了黄曲霉毒素(AFB1)、脱氧雪腐镰刀菌烯醇(DON)、赭曲霉毒素(OTA)、伏马毒素(FB1)、T-2毒素等多种真菌毒素对组蛋白修饰影响的最新研究进展及其可能的作用机制,为进一步揭示环境毒素污染对人体健康的影响及食品安全风险评估提供了参考依据。The exposure of naturally occurring mycotoxins affects human health and plays a vital role in cancer initiation and progression. Increasing evidences indicated that exposure to mycotoxin was associated with many diseases. Many mycotoxins have been proved to alter the histone modification status,such epigenetic changes are related to the occurrence and development of many disease. Recently,the mode of mycotoxins epigenetic research has been advanced in research hotspots. However,there is still no study on histone modification of mycotoxin-induced toxicity. In this paper,the effects of several mycotoxins including aflatoxin（ AFB1）,deoxynivalenol（ DON）,ochratoxin（ OTA）,fumonisim B1（ FB1） and T-2 toxin on histone modification,and the involved pathogenic mechanisms were reviewed. This may be helpful for revealing effects of mycotoxin contamination on human healthy and provide a reference for assessment of food safety risk.

关 键 词：真菌毒素 表观遗传 组蛋白修饰 食品安全 

分 类 号：TS201.6[轻工技术与工程—食品科学]