鳕鱼皮胶原蛋白肽果汁饮料抗紫外线照射引起的皮肤光老化  

Effect of Fruit Juice Drink Containing Collagen Polypeptides from Pacific cod(Gadus macrocephalus) Skin on UV Irradiation-induced Skin Photoaging

作　　者：初鑫 宋韶乾 司磊磊[1] 侯虎[1] 赵雪[1] 李八方[1] CHU Xin;SONG Shao-qian;SI Lei-lei;HOU Hu;ZHAO Xue;LI Ba-fang(College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China)

机构地区：[1]中国海洋大学食品科学与工程学院,山东青岛266003

出　　处：《食品工业科技》2018年第22期287-292,共6页Science and Technology of Food Industry

基　　金：国家自然科学基金(31401476)

摘　　要：为研究鳕鱼皮胶原蛋白肽果汁饮料(CJD)对紫外线诱导的皮肤光老化的调节作用,将ICR雄性小鼠随机分为正常组(NC)、模型组(MC)、CJD低剂量组(CJD-L)、中剂量组(CJD-M)和高剂量组(CJD-H),通过观察各组小鼠造模部位皮肤的表观特征、结合HE染色,皮肤中羟脯氨酸和水分的含量来评价CJD对小鼠皮肤光老化的防护作用;通过测定小鼠皮肤组织和血清中的总超氧化物歧化酶(T-SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)的活力,丙二醛(MDA)的含量,来探究CJD对皮肤光老化的作用途径。结果显示,与MC组相比,CJD中剂量和高剂量组可以显著抑制光老化小鼠皮肤中水分的流失(p <0.05)及胶原含量的降低(p <0.01),显著提高小鼠皮肤组织和血清中T-SOD、GSH-Px、CAT的活力(p <0.05),显著降低MDA的含量(p <0.05)。研究表明,胶原蛋白肽饮料对紫外线引起的皮肤光老化有保护作用,能够有效预防和延缓光老化。The protective effect of cod-skin collagen peptide combining juice drink（ CJD） on UV Irradiation-induced skin photoaging was investigated.Male ICR mice were randomly divided into five groups： normal group（ NC）,model group（ MC）,low dose CJD treatment group（ CJD-L）,medium dose CJD treatment group（ CJD-M） and high dose CJD treatment group（ CJD-H）.The protective effect of CJD on photoaging was evaluated by clinical signs,histological morphology,content of water and hydroxyproline of UV-irradiation mice skin.The activities of total superoxide dismutase（ T-SOD）,catalase（ CAT）,glutathione peroxidase（ GSH-Px） and the level of malondialdehyde（ MDA） in skin and serum were assessed to explore the pathway of protection of CJD on UV Irradiation-induced skin photoaging.Compared with the model group,the CJD-M and CJD-H groups significantly reduced water loss（ p〈0.05） and collagen breakdown of photoaging skin（ p〈0.01）,significantly enhanced activity of T-SOD,CAT,GSH-Px and decreased levels of MDA in skin and serum（ p〈0.05）.This study showed that collagen peptide drinks could protect skin against UV irradiation-induced photodamage,which could effectively prevent and delay photoaging.

关 键 词：鳕鱼皮 胶原蛋白肽 紫外照射 皮肤光老化 抗氧化酶 

分 类 号：TS275.5[轻工技术与工程—农产品加工及贮藏工程]