不同诱导物对内皮细胞氧化损伤作用的研究进展  

Progress in Research on Effects of Different Inducers on Oxidative Damage in Endothelial Cells

作　　者：梁盈[1] 李佳佳[1] 黄萍[1] 马酉初 刘一超[1] 林亲录[1] LIANG Ying;LI Jiajia;HUANG Ping;MA Youchu;LIU Yichao;LIN Qinlu(National Engineering Laboratory for Rice and By-Product Deep Processing, Central South University of Forestry and Technology, Changsha 410004, China)

机构地区：[1]中南林业科技大学稻谷及副产物深加工国家工程实验室,湖南长沙410004

出　　处：《食品科学》2017年第15期265-270,共6页Food Science

基　　金：国家自然科学基金青年科学基金项目(31201348);国家自然科学基金面上项目(31571874);湖南省自然科学基金面上项目(2017JJ2410);湖湘青年科技创新人才项目(2016RS3033);粮油深加工与品质控制2011湖南省协同创新项目;中南林业科技大学研究生教材建设项目(2015JC03)

摘　　要：高血压、动脉粥样硬化等心脑血管疾病的发病率逐年增加,这是严重危害人类健康生活的一类疾病,而内皮细胞氧化损伤往往是这些疾病早期的共同反应。不仅如此,一些治疗如物理治疗、心脏手术等会遗留一些影响内皮细胞功能的问题。因此,该领域研究者们对内皮细胞氧化损伤的机制研究越来越重视,并以此寻找合适的效应物如食品中的活性成分来抑制内皮细胞的氧化,减少和防治相关疾病的发生。本文综述了内皮细胞氧化损伤研究中几种常用诱导物如过氧化氢、氧化低密度脂蛋白、高糖、辐射等对内皮细胞氧化损伤的作用和特点,供研究人员根据研究方向选择合适的诱导物来建立内皮细胞氧化损伤模型,以此更有针对性地进行效应物的筛选及作用机制的研究。Nowadays,the incidence of hypertension,atherosclerosis and other cardiovascular and cerebrovascular diseases,which threaten human health,increases year by year.Previous studies showed that oxidative damage in endothelial cells was usually a common response at the early stage of these diseases.Moreover,some therapeutic strategies such as physical therapy and cardiac surgery may leave some problems affecting endothelial function.In this context,the mechanism of oxidative damage in endothelial cells is of growing interest to researchers,and many efforts have been made to seek the most suitable effectors like active components derived from foods to inhibit oxidative damage in endothelial cells,thereby preventing or reducing the occurrence of related diseases.The mechanisms of action of several common inducers such as hydrogen peroxide,oxidized low-density lipoprotein,high glucose concentration and radiation in causing oxidative damage in endothelial cells are described in this review,which will provide valuable information to select a suitable inducer for induction of oxidative damage in endothelial cells and therefore to facilitate the selection of effectors and the study of the underlying mechanism.

关 键 词：内皮细胞 氧化损伤 诱导物 

分 类 号：TS201.4[轻工技术与工程—食品科学]