Pathogenesis of Chagas disease cardiomyopathy  

作　　者：Priscila Camillo Teixeira Amanda Farrage Frade Luciana Gabriel Nogueira Jorge Kalil Christophe Chevillard Edecio Cunha-Neto 

机构地区：[1]Labora-tory of Immunology, Heart Institute (Incor), School of Medicine, University of Sao Paulo [2]Institute for Investigation in Immunology (III), INCT [3]Division of Clinical Immunol-ogy and Allergy, School of Medicine, University of Sao Paulo [4]INSERM [5]Aix-Marseille University

出　　处：《World Journal of Clinical Infectious Diseases》2012年第3期39-53,共15页世界临床传染病学杂志

基　　金：Supported by the Institut National de la Santéet de la Recherche Médicale;the Aix-Marseille University(Direction des Relations Internationales);USP-COFECUB program;the ARCUS II PACA Brésil program;CNPq(Brazilian National Research Council);FAPESP(S?o Paulo State Research Funding Agency-Brazil).

摘　　要：Chagas disease, or American trypanosomiasis, is a parasitic infection caused by the flagellate protozoanTrypanosoma cruzi. Chagas disease is mainly affecting rural populations in Mexico and Central and South America. The World Health Organization estimates that 300 000 new cases of Chagas disease occur every year and approximately 20 000 deaths are attributable to Chagas. However, this organisation classified Chagas disease as a neglected tropical disease. The economic burden of this disease is significant. In many Latin American countries, the direct and indirect costs, including the cost of health care in dollars and loss of productivity, attributable to Chagas disease ranges from $40 million to in excess of $800 million per nation per annum. So, it remains a contemporary public health concern. In chronic phase, mortality is primarily due to the rhythm disturbances and congestive heart failure that result from the chronic inflammatory cardiomyopathy(CCC) due to the persistence presence of parasites in the heart tissue. Mechanisms underlying differential progression to CCC are still incompletely understood. In the last decades immunological proteomic genetic approaches lead to significant results which help to disperse the veil covering the knowledge of the pathogenic process. Here, we reported these significant progresses.Chagas disease, or American trypanosomiasis, is a parasitic infection caused by the flagellate protozoanTrypanosoma cruzi. Chagas disease is mainly affecting rural populations in Mexico and Central and South America. The World Health Organization estimates that 300 000 new cases of Chagas disease occur every year and approximately 20 000 deaths are attributable to Chagas. However, this organisation classified Chagas disease as a neglected tropical disease. The economic burden of this disease is significant. In many Latin American countries, the direct and indirect costs, including the cost of health care in dollars and loss of productivity, attributable to Chagas disease ranges from $40 million to in excess of $800 million per nation per annum. So, it remains a contemporary public health concern. In chronic phase, mortality is primarily due to the rhythm disturbances and congestive heart failure that result from the chronic inflammatory cardiomyopathy(CCC) due to the persistence presence of parasites in the heart tissue. Mechanisms underlying differential progression to CCC are still incompletely understood. In the last decades immunological proteomic genetic approaches lead to significant results which help to disperse the veil covering the knowledge of the pathogenic process. Here, we reported these significant progresses.

关 键 词：CHAGAS PATHOGENESIS CARDIOMYOPATHY SUSCEPTIBILITY PARASITIC 

分 类 号：R[医药卫生]